Golder Su, Wright Kath, Rodgers Mark
Centre for Reviews and Dissemination (CRD),University of York,
Int J Technol Assess Health Care. 2014 Oct;30(4):423-9. doi: 10.1017/S0266462314000506. Epub 2014 Nov 11.
The most effective sources to search to identify adverse effects data for medical devices are currently unknown.
The included studies from a systematic review of the safety of recombinant human bone morphogenetic protein-2 (rhBMP-2) for spinal fusion were used for analysis. For each source searched, a record was made for each relevant publication of whether it was retrieved by the search strategy used and whether it was available in the database but not retrieved. To account for multiple publications of the same study, a record was made of the relevant studies identified. The sensitivity, precision, and number needed to read were calculated as well as the minimum combination of sources to identify all the publications or studies.
There were eighty-two publications (forty-nine studies) included in the systematic review. Only one article was available in a database searched but not retrieved by our search strategy. Science Citation Index (SCI) and EMBASE both achieved the highest sensitivity (62 percent), followed closely by MEDLINE/PubMED (56 percent). With the search strategies used, the minimum combination of sources needed to identify all the publications was SCI, EMBASE, CENTRAL, and either MEDLINE or PubMED, in addition to reference checking, contacting authors and an automated current awareness service. In relation to identifying all the relevant studies, the minimum combination of studies was similar with the exclusion of CENTRAL.
To identify all the relevant publications or studies included in this case study systematic review, several different sources needed to be searched.
目前尚不清楚用于识别医疗器械不良反应数据的最有效检索来源。
对重组人骨形态发生蛋白-2（rhBMP-2）用于脊柱融合的安全性进行系统评价时纳入的研究用于分析。对于每个检索的来源，记录每个相关出版物是否通过所使用的检索策略被检索到，以及它是否在数据库中但未被检索到。为了考虑同一研究的多篇出版物，记录所识别的相关研究。计算了敏感度、精准度和阅读所需数量，以及识别所有出版物或研究的来源的最小组合。
系统评价纳入了82篇出版物（49项研究）。在检索的数据库中只有一篇文章可获取，但未被我们的检索策略检索到。科学引文索引（SCI）和EMBASE的敏感度均最高（62%），紧随其后的是MEDLINE/PubMED（56%）。使用所采用的检索策略，识别所有出版物所需的来源的最小组合是SCI、EMBASE、CENTRAL以及MEDLINE或PubMED中的一个，此外还需进行参考文献核对、联系作者以及使用自动的现况报道服务。关于识别所有相关研究，研究的最小组合类似，但不包括CENTRAL。
为了识别本案例研究系统评价中纳入的所有相关出版物或研究，需要检索几个不同的来源。
