Ruwanpathirana Thilanga, Reid Christopher M, Owen Alice J, Fong David P S, Gowda Usha, Renzaho Andre M N
Centre for Cardiovascular Research and Education in Therapeutics, Department of Epidemiology and Preventive Medicine, Monash University, The Alfred Centre, Melbourne, Victoria, Australia.
BMC Cardiovasc Disord. 2014 Nov 11;14:157. doi: 10.1186/1471-2261-14-157.
Vitamin D deficiency is a global public health problem associated with increased risk of cardio-metabolic diseases and osteoarthritis. Migrants with dark skin settled in temperate climates are at greater risk of both vitamin D deficiency and cardiovascular diseases. This study aims to identify the risk of vitamin D deficiency and associations with cardiovascular disease in a migrant population in Australia.
An audit was carried out at a Community Health Service in Kensington, Melbourne which, services a large migrant population. Data from the clinical records of all adults who visited the medical centre at least once during the period from 1st January 2010 to 31st December 2012 was extracted. The future (10 year) coronary heart disease risk was estimated using Framingham Risk Score.
The centre has given higher priority to vitamin D testing in migrants, those middle-aged, females and those with diabetes and osteoarthritis. Migrants from countries located in lower latitude regions (Latitude N230 to S230) were 1.48 (95% C.I. 1.32-1.65) times more likely to develop vitamin D deficiency post migration and 0.44 (95% C.I. 0.31-0.62) times less likely to have a >15% 10-year risk of coronary heart disease when compared to their Australian-born counterparts.
Adherence to a high risk strategy for vitamin D testing was observed in the centre. Pre-migration latitude is an important factor for vitamin D deficiency (lower the latitude higher the risk) and in predicting future risk of cardiovascular disease in migrants. These findings suggest that a targeted approach for vitamin D testing, including zone of origin might better identify individuals at higher risk of both vitamin D deficiency and cardiovascular disease.
维生素D缺乏是一个全球性的公共卫生问题,与心血管代谢疾病和骨关节炎风险增加相关。定居在温带气候地区的深色皮肤移民患维生素D缺乏症和心血管疾病的风险更高。本研究旨在确定澳大利亚移民人群中维生素D缺乏的风险及其与心血管疾病的关联。
在墨尔本肯辛顿的一个社区卫生服务中心进行了一项审计,该中心为大量移民人群提供服务。提取了2010年1月1日至2012年12月31日期间至少去过一次医疗中心的所有成年人的临床记录数据。使用弗明汉风险评分法估计未来(10年)冠心病风险。
该中心更优先对移民、中年人群、女性以及患有糖尿病和骨关节炎的人群进行维生素D检测。与澳大利亚出生的同龄人相比,来自低纬度地区(北纬23°至南纬23°)国家的移民在移民后患维生素D缺乏症的可能性高1.48倍(95%置信区间1.32 - 1.65),而10年冠心病风险>15%的可能性低0.44倍(95%置信区间0.31 - 0.62)。
该中心遵循了针对维生素D检测的高风险策略。移民前的纬度是维生素D缺乏的一个重要因素(纬度越低风险越高),并且在预测移民未来心血管疾病风险方面也很重要。这些发现表明,一种有针对性的维生素D检测方法,包括考虑原籍地区,可能会更好地识别维生素D缺乏和心血管疾病风险较高的个体。