McLean S
Department of Neuroscience and Cancer, Pfizer Pharmaceuticals, Connecticut 06340.
Prog Clin Biol Res. 1989;286:109-28.
Receptor binding methods provide the most direct measure of drug-receptor interaction currently available. They provide information, inexpensively, rapidly, and reliably on the interaction of chemical agents with receptors. Furthermore, receptor binding may be used to gain insight into receptor dysfunctions that may underlie a variety of diseases. Binding studies have been and will continue to be important in identifying the locus of action of psychotherapeutic drugs. This is not to suggest that in vivo testing should be supplanted by receptor binding assays, but that these assays represent a powerful weapon in the drug discovery team's armementarium and should not be overlooked.
受体结合方法是目前可获得的药物与受体相互作用最直接的测量方法。它们能廉价、快速且可靠地提供有关化学试剂与受体相互作用的信息。此外，受体结合可用于深入了解可能是多种疾病基础的受体功能障碍。结合研究在确定精神治疗药物的作用位点方面一直很重要，而且将继续如此。这并不是说体内测试应被受体结合测定所取代，而是说这些测定是药物研发团队武器库中的有力武器，不应被忽视。
