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Randomised controlled trials for Ebola: practical and ethical issues.埃博拉病毒的随机对照试验:实践与伦理问题
Lancet. 2014 Oct 18;384(9952):1423-4. doi: 10.1016/S0140-6736(14)61734-7. Epub 2014 Oct 13.
2
Antiviral therapeutics for the treatment of Ebola virus infection.用于治疗埃博拉病毒感染的抗病毒疗法。
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3
Randomisation is essential in Ebola drug trials.随机化在埃博拉药物试验中至关重要。
Lancet. 2014 Nov 8;384(9955):1667. doi: 10.1016/S0140-6736(14)61735-9. Epub 2014 Oct 27.
4
Drug and vaccine access in the Ebola epidemic: advising caution in compassionate use.埃博拉疫情中的药物和疫苗获取:建议谨慎进行同情用药。
Ann Intern Med. 2015 Jan 20;162(2):141-2. doi: 10.7326/M14-2002.
5
A US Food and Drug Administration perspective on evaluating medical products for Ebola.美国食品药品监督管理局对埃博拉医疗产品评估的观点。
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Prioritising Healthcare Workers for Ebola Treatment: Treating Those at Greatest Risk to Confer Greatest Benefit.优先考虑让医护人员接受埃博拉治疗:治疗风险最高者以获最大益处。
Dev World Bioeth. 2015 Aug;15(2):59-67. doi: 10.1111/dewb.12079. Epub 2015 Feb 6.
7
Ethical allocation of drugs and vaccines in the West African ebola epidemic.西非埃博拉疫情中药物和疫苗的伦理分配
Milbank Q. 2014 Dec;92(4):662-6. doi: 10.1111/1468-0009.12089.
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[Not Available].[不可用]。
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A viewpoint on European Medicines Agency experience with investigational medicinal products for Ebola.关于欧洲药品管理局在埃博拉病毒研究用药品方面经验的观点
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Development of Small-Molecule Antivirals for Ebola.用于治疗埃博拉的小分子抗病毒药物的研发
Med Res Rev. 2015 Nov;35(6):1175-94. doi: 10.1002/med.21355. Epub 2015 Jul 14.

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Regulator experiences of trials during Ebola epidemics in Sierra Leone, Guinea, and the Democratic Republic of the Congo.塞拉利昂、几内亚和刚果民主共和国埃博拉疫情期间试验的监管经验。
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Strengthening and expanding capacities in clinical trials: advancing pandemic prevention, preparedness and response in Africa.加强和扩大临床试验能力:推进非洲大流行病的预防、防备和应对。
Nat Commun. 2024 Oct 7;15(1):8662. doi: 10.1038/s41467-024-53126-3.
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Evaluating quasi-experimental approaches for estimating epidemiological efficacy of non-randomised field trials: applications in Wolbachia interventions for dengue.评估非随机现场试验估计流行病学效果的准实验方法:在沃尔巴克氏体干预登革热中的应用。
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CURE: A deep learning framework pre-trained on large-scale patient data for treatment effect estimation.CURE:一个在大规模患者数据上进行预训练以估计治疗效果的深度学习框架。
Patterns (N Y). 2024 May 1;5(6):100973. doi: 10.1016/j.patter.2024.100973. eCollection 2024 Jun 14.
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The Ethical Obligation for Research During Public Health Emergencies: Insights From the COVID-19 Pandemic.突发公共卫生事件中的研究伦理义务:COVID-19 大流行带来的启示。
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Towards achieving transnational research partnership equity: lessons from implementing adaptive platform trials in low- and middle-income countries.迈向实现跨国研究伙伴关系公平:在低收入和中等收入国家开展适应性平台试验的经验教训。
Wellcome Open Res. 2023 Dec 6;8:120. doi: 10.12688/wellcomeopenres.18915.2. eCollection 2023.
7
Research ethics during infectious disease outbreaks: A survey of African research stakeholders using the Ebola virus disease outbreak as a case.传染病暴发期间的研究伦理:以埃博拉病毒病暴发为例对非洲研究利益相关者的调查
J Public Health Afr. 2023 Oct 24;14(9):1632. doi: 10.4081/jphia.2023.1632. eCollection 2023 Oct 1.
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Key ethical issues encountered during COVID-19 research: a thematic analysis of perspectives from South African research ethics committees.在 COVID-19 研究中遇到的关键伦理问题:南非研究伦理委员会观点的主题分析。
BMC Med Ethics. 2023 Feb 15;24(1):11. doi: 10.1186/s12910-023-00888-y.
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[French research organization on emerging infectious diseases: From REACTing to ANRS emerging infectious diseases].[法国新兴传染病研究组织:从应对到法国国家艾滋病研究机构新兴传染病研究]
Bull Acad Natl Med. 2023 Mar;207(3):287-294. doi: 10.1016/j.banm.2022.11.017. Epub 2023 Jan 18.
10
Ethical and epistemic issues in the design and conduct of pragmatic stepped-wedge cluster randomized clinical trials.实用型阶梯式群组随机临床试验设计与实施中的伦理和认识问题。
Contemp Clin Trials. 2022 Apr;115:106703. doi: 10.1016/j.cct.2022.106703. Epub 2022 Feb 15.

本文引用的文献

1
Evaluating novel therapies during the Ebola epidemic.在埃博拉疫情期间评估新型疗法。
JAMA. 2014 Oct 1;312(13):1299-300. doi: 10.1001/jama.2014.12867.

Randomised controlled trials for Ebola: practical and ethical issues.

作者信息

Adebamowo Clement, Bah-Sow Oumou, Binka Fred, Bruzzone Roberto, Caplan Arthur, Delfraissy Jean-François, Heymann David, Horby Peter, Kaleebu Pontiano, Tamfum Jean-Jacques Muyembe, Olliaro Piero, Piot Peter, Tejan-Cole Abdul, Tomori Oyewale, Toure Aissatou, Torreele Els, Whitehead John

机构信息

National Health Research Ethics Committee, Abuja, Nigeria.

Hôpital National Ignace Deen, Conakry, Guinea.

出版信息

Lancet. 2014 Oct 18;384(9952):1423-4. doi: 10.1016/S0140-6736(14)61734-7. Epub 2014 Oct 13.

DOI:10.1016/S0140-6736(14)61734-7
PMID:25390318
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4392883/
Abstract
摘要