• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

Rapid evolution of combination therapy in melanoma.

作者信息

Curti Brendan D

机构信息

From the Earle A. Chiles Research Institute, Providence Cancer Center, Portland, OR.

出版信息

N Engl J Med. 2014 Nov 13;371(20):1929-30. doi: 10.1056/NEJMe1411158.

DOI:10.1056/NEJMe1411158
PMID:25390744
Abstract
摘要

相似文献

1
Rapid evolution of combination therapy in melanoma.黑色素瘤联合治疗的快速发展
N Engl J Med. 2014 Nov 13;371(20):1929-30. doi: 10.1056/NEJMe1411158.
2
Skin cancer: BRAF and MEK inhibitors-good news comes in twos!皮肤癌：BRAF和MEK抑制剂——好消息成双而至！
Nat Rev Clin Oncol. 2014 Dec;11(12):683. doi: 10.1038/nrclinonc.2014.183. Epub 2014 Oct 21.
3
Management of Treatment-Related Adverse Events with Agents Targeting the MAPK Pathway in Patients with Metastatic Melanoma.转移性黑色素瘤患者中使用靶向MAPK通路药物治疗相关不良事件的管理
Oncologist. 2017 Jul;22(7):823-833. doi: 10.1634/theoncologist.2016-0456. Epub 2017 May 18.
4
Comparative profile of cutaneous adverse events: BRAF/MEK inhibitor combination therapy versus BRAF monotherapy in melanoma.皮肤不良事件的比较概况：黑色素瘤中BRAF/MEK抑制剂联合疗法与BRAF单药疗法的对比
J Am Acad Dermatol. 2014 Dec;71(6):1102-1109.e1. doi: 10.1016/j.jaad.2014.09.002. Epub 2014 Oct 16.
5
Development of Cutaneous Toxicities During Selective Anti-BRAF Therapies: Preventive Role of Combination with MEK Inhibitors.选择性抗BRAF治疗期间皮肤毒性的发生：与MEK抑制剂联合使用的预防作用
Acta Derm Venereol. 2017 Feb 8;97(2):258-260. doi: 10.2340/00015555-2488.
6
Successful re-challenge with anti-BRAF and anti-MEK in a patient with symptomatic melanoma flare.一名有症状性黑色素瘤发作的患者成功再次接受抗BRAF和抗MEK治疗。
Eur J Cancer. 2017 Sep;82:25-26. doi: 10.1016/j.ejca.2017.05.039. Epub 2017 Jun 21.
7
MAP-kinase pathway up or down? Just look at the skin of your patients!丝裂原活化蛋白激酶信号通路是上调还是下调？看看你患者的皮肤就知道了！
Melanoma Res. 2014 Oct;24(5):421-3. doi: 10.1097/CMR.0000000000000114.
8
Epidermotropic progression of melanoma during therapy with vemurafenib and trametinib.维莫非尼和曲美替尼治疗期间黑色素瘤的表皮趋向性进展
J Am Acad Dermatol. 2016 Oct;75(4):e133-e135. doi: 10.1016/j.jaad.2016.03.006.
9
[The Role of BRAF/MEK Inhibition in Metastatic Malignant Melanoma - a Case Study].[BRAF/MEK 抑制在转移性恶性黑色素瘤中的作用——病例研究]
Klin Onkol. 2016;29(2):133-8. doi: 10.14735/amko2016133.
10
Improved overall survival in melanoma with combined dabrafenib and trametinib.达拉非尼和曲美替尼联合治疗可改善黑色素瘤患者的总生存期。
N Engl J Med. 2015 Jan 1;372(1):30-9. doi: 10.1056/NEJMoa1412690. Epub 2014 Nov 16.

引用本文的文献

1
Head and neck melanoma (excluding ocular melanoma): United Kingdom National Multidisciplinary Guidelines.头颈部黑色素瘤（不包括眼部黑色素瘤）：英国国家多学科指南
J Laryngol Otol. 2016 May;130(S2):S133-S141. doi: 10.1017/S0022215116000852.
2
A Novel Plant Sesquiterpene Lactone Derivative, DETD-35, Suppresses BRAFV600E Mutant Melanoma Growth and Overcomes Acquired Vemurafenib Resistance in Mice.一种新型植物倍半萜内酯衍生物DETD-35可抑制BRAFV600E突变型黑色素瘤生长并克服小鼠对维莫非尼的获得性耐药。
Mol Cancer Ther. 2016 Jun;15(6):1163-76. doi: 10.1158/1535-7163.MCT-15-0973. Epub 2016 Apr 5.
3
MEK inhibitors and their potential in the treatment of advanced melanoma: the advantages of combination therapy.
MEK抑制剂及其在晚期黑色素瘤治疗中的潜力：联合治疗的优势
Drug Des Devel Ther. 2015 Dec 21;10:43-52. doi: 10.2147/DDDT.S93545. eCollection 2016.
4
Novel risk scores for survival and intracranial failure in patients treated with radiosurgery alone to melanoma brain metastases.仅接受放射外科治疗的黑色素瘤脑转移患者生存和颅内失败的新型风险评分。
Radiat Oncol. 2015 Dec 1;10:248. doi: 10.1186/s13014-015-0553-y.
5
Tailoring the Treatment of Melanoma: Implications for Personalized Medicine.黑色素瘤治疗的精准定制：对个性化医疗的启示
Yale J Biol Med. 2015 Nov 24;88(4):389-95. eCollection 2015 Dec.
6
Matrix metalloproteinase-12 expression is increased in cutaneous melanoma and associated with tumor aggressiveness.基质金属蛋白酶-12在皮肤黑色素瘤中的表达增加，并与肿瘤侵袭性相关。
Tumour Biol. 2015 Nov;36(11):8593-600. doi: 10.1007/s13277-015-3622-9. Epub 2015 Jun 4.
7
Trametinib in the treatment of melanoma.曲美替尼治疗黑色素瘤。
Expert Opin Biol Ther. 2015 May;15(5):735-47. doi: 10.1517/14712598.2015.1026323. Epub 2015 Mar 26.