内皮素增强灌注大鼠肠系膜动脉中的肾上腺素能血管收缩作用。

Endothelin enhances adrenergic vasoconstriction in perfused rat mesenteric arteries.

作者信息

Tabuchi Y, Nakamaru M, Rakugi H, Nagano M, Ogihara T

机构信息

Department of Geriatric Medicine, Osaka University Medical School, Japan.

出版信息

Biochem Biophys Res Commun. 1989 Mar 31;159(3):1304-8. doi: 10.1016/0006-291x(89)92252-3.

DOI:10.1016/0006-291x(89)92252-3

PMID:2539151

Abstract

The interaction of endothelin with alpha-adrenergic receptors was examined in isolated perfused rat mesenteric arteries. Infusion of porcine or rat endothelin increased the baseline perfusion pressure dose-dependently. Subpressor doses of both porcine (10(-11) and 10(-10)M) and rat (10(-10) and 10(-9)M) endothelin enhanced the pressor responses to norepinephrine. Nicardipine (10(-7)M), a calcium channel blocker, attenuated this potentiation. These results suggest that endothelin enhances the responsiveness of alpha-adrenergic receptors to catecholamines probably through the increase in calcium influx. Thus endothelin may interact with sympathetic nerve activity in addition to having a direct vasoconstrictor action in peripheral vascular tissue.

摘要

在离体灌注的大鼠肠系膜动脉中研究了内皮素与α-肾上腺素能受体的相互作用。输注猪或大鼠内皮素可使基础灌注压剂量依赖性增加。猪（10⁻¹¹和10⁻¹⁰M）和大鼠（10⁻¹⁰和10⁻⁹M）内皮素的亚升压剂量增强了对去甲肾上腺素的升压反应。钙通道阻滞剂尼卡地平（10⁻⁷M）减弱了这种增强作用。这些结果表明，内皮素可能通过增加钙内流来增强α-肾上腺素能受体对儿茶酚胺的反应性。因此，内皮素除了在周围血管组织中具有直接的血管收缩作用外，还可能与交感神经活动相互作用。