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背根切断术后大鼠体内μ和δ阿片受体结合位点及中性内肽酶-24.11的放射自显影研究

Autoradiographic study of mu and delta opioid binding sites and neutral endopeptidase-24.11 in rat after dorsal root rhizotomy.

作者信息

Zajac J M, Lombard M C, Peschanski M, Besson J M, Roques B P

机构信息

I.N.S.E.R.M. U. 266, C.N.R.S. U.A. 498, Paris, France.

出版信息

Brain Res. 1989 Jan 16;477(1-2):400-3. doi: 10.1016/0006-8993(89)91436-4.

DOI:10.1016/0006-8993(89)91436-4
PMID:2539237
Abstract

Highly selective tritiated ligands and autoradiography have been used to study mu and delta binding sites as well as neutral endopeptidase-24.11 in the dorsal horn of the rat spinal cord. Two weeks and 4 months after dorsal root rhizotomy, both opioid binding sites were dramatically decreased (congruent to 60%). In contrast, the level of neutral endopeptidase-24.11 remained unaltered.

摘要

高选择性氚化配体和放射自显影术已被用于研究大鼠脊髓背角中的μ和δ结合位点以及中性内肽酶-24.11。在背根切断术后两周和四个月，两种阿片样物质结合位点均显著减少（约60%）。相比之下，中性内肽酶-24.11的水平保持不变。

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