铁（II）离子与戊糖2-脱氧核糖的结合。
Binding of iron(II) ions to the pentose sugar 2-deoxyribose.
作者信息
Aruoma O I, Chaudhary S S, Grootveld M, Halliwell B
机构信息
Department of Biochemistry, University of London King's College, U.K.
出版信息
J Inorg Biochem. 1989 Feb;35(2):149-55. doi: 10.1016/0162-0134(89)80007-8.
Iron(II) ions are able to form a weak complex (apparent equilibrium constant about 10(2) at pH 7.4 and 25 degrees C) with 2-deoxyribose over a range of pH values, including pH 7. Evidence for this complex formation has been obtained by spectrophotometric experiments and by studies of Fe(II) oxidation. Iron(II) ions bound to deoxyribose seem to react with H2O2, in a site-specific reaction, to form hydroxyl radicals (.OH) that immediately damage the deoxyribose molecule.
在包括pH 7在内的一系列pH值范围内，亚铁离子能够与2-脱氧核糖形成一种弱络合物（在pH 7.4和25℃时表观平衡常数约为10²）。通过分光光度实验和亚铁离子氧化研究已获得了这种络合物形成的证据。与脱氧核糖结合的亚铁离子似乎在一个位点特异性反应中与过氧化氢反应，形成立即破坏脱氧核糖分子的羟基自由基（·OH）。
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