Flanagan L M, Verbalis J G, Stricker E M
Department of Behavioral Neuroscience, University of Pittsburgh, Pennsylvania 15260.
Am J Physiol. 1989 Apr;256(4 Pt 2):R955-61. doi: 10.1152/ajpregu.1989.256.4.R955.
In these experiments we examined the effects on gastric motility of cholecystokinin, LiCl, hypertonic NaCl solution, gastric distension, and intraduodenal glucose loads, five dissimilar treatments known to reduce food intake in rats. In addition, we investigated whether any observed effects were dependent on the afferent vagus nerve by pretreating subjects with the neurotoxin capsaicin. Each of the five treatments virtually eliminated the gastric contractions seen after rats had consumed a large meal of chow; these effects were rapid in onset and continued for up to 30 min. The inhibitory effects of cholecystokinin and gastric distension were eliminated by pretreatment with capsaicin, whereas the effects of the other treatments were attenuated only slightly or not at all. Because most of these treatments have been shown to stimulate pituitary oxytocin secretion in rats as well as to inhibit food intake and gastric motility, these results are consistent with the hypothesis that the hypothalamic paraventricular nucleus is a site at which information is integrated in the coordinated control of food intake, gastric function, and neuroendocrine secretion.
在这些实验中，我们研究了胆囊收缩素、氯化锂、高渗氯化钠溶液、胃扩张和十二指肠内葡萄糖负荷对胃动力的影响，这五种不同的处理方法均已知可减少大鼠的食物摄入量。此外，我们通过用神经毒素辣椒素预处理实验对象，研究了任何观察到的效应是否依赖于传入迷走神经。五种处理方法中的每一种实际上都消除了大鼠进食大量食物后出现的胃收缩；这些效应起效迅速，持续长达30分钟。胆囊收缩素和胃扩张的抑制作用通过辣椒素预处理而消除，而其他处理方法的效应仅略有减弱或根本未减弱。由于这些处理方法中的大多数已被证明可刺激大鼠垂体催产素分泌，同时抑制食物摄入和胃动力，因此这些结果与以下假设一致，即下丘脑室旁核是一个在食物摄入、胃功能和神经内分泌分泌的协调控制中整合信息的部位。
