Shaw P, Costa J
Institute of Pathology, Faculty of Medicine, University of Lausanne, Switzerland.
Anticancer Res. 1989 Jan-Feb;9(1):21-7.
In recent years molecular biology has been applied to the study of colonic carcinoma, both in the human and in the experimental animal. The data obtained have enriched our understanding of colonic carcinogenesis and are of potential interest for cancer diagnosis and prevention. In this paper we review part of the available literature on the molecular characterisation of colon tumors, with emphasis on the issues of clonality, in vitro cell lines, tumor progression and heredity of colon cancer.
近年来，分子生物学已被应用于人类和实验动物结肠癌的研究。所获得的数据丰富了我们对结肠癌发生机制的理解，并且对癌症的诊断和预防具有潜在的意义。在本文中，我们综述了部分关于结肠肿瘤分子特征的现有文献，重点关注克隆性、体外细胞系、肿瘤进展和结肠癌遗传等问题。
