Department of Psychiatry,University of Louisville School of Medicine,Louisville,KY,USA.
Acta Neuropsychiatr. 2015 Feb;27(1):53-5. doi: 10.1017/neu.2014.31. Epub 2014 Nov 14.
Orexin, also called hypocretin, is a neuropeptide that acts on central nervous system receptors to promote arousal. Suvorexant, its receptor antagonist, generates interest as a medication to treat insomnia. Suvorexant helps in decreasing wakefulness by counteracting orexin activity. Its low side effect potential may offer considerable benefit. Compared with other sleep aids, diminished drowsiness and less cognitive dysfunction is an advantage. Now approved for clinical use, an apparent lack of rebound insomnia or drug dependence potential might make suvorexant a good choice pharmacotherapy for patients with insomnia.
食欲素，也被称为下丘脑泌素，是一种作用于中枢神经系统受体以促进觉醒的神经肽。其受体拮抗剂苏沃雷生作为一种治疗失眠的药物引起了人们的兴趣。苏沃雷生通过拮抗食欲素的活性来帮助减少觉醒。它的低副作用潜力可能带来相当大的好处。与其他助眠药物相比，它能减少嗜睡和认知功能障碍，具有优势。现在已被批准用于临床，其明显缺乏反弹性失眠或药物依赖的可能性使其成为治疗失眠症患者的一种较好的药物治疗选择。
