Uzunlar Ozlem, Engin-Ustun Yaprak, Ozyer Sebnem, Danısman Nuri, Candar Tuba, Keskin Senem M, Mollamahmutoglu Leyla
Obstetrics and Gynecology Department, Zekai Tahir Burak Women Health Training and Research Hospital, Ankara, Turkey,
Arch Gynecol Obstet. 2015 May;291(5):1069-74. doi: 10.1007/s00404-014-3540-x. Epub 2014 Nov 16.
The aim of this study was to estimate the level of liver fatty acid binding protein (LFABP) in women with preeclampsia.
A case-control study was conducted in 90 pregnant women who were divided into the following three groups: normal pregnancy (n = 30), mild-moderate preeclampsia (n = 30), and severe preeclampsia (n = 30). Maternal blood samples were obtained during an antenatal clinic visit in normal pregnant women, and at the time of diagnosis in women with preeclampsia. Serum LFABP levels were measured by the quantitative sandwich enzyme immunoassay technique.
Serum LFABP level was significantly higher in severe and mild-moderate preeclampsia groups than normal pregnancy group (1,709.90 ± 94.82, 1,614.93 ± 118.22, and 1,532.36 ± 140.98 pg/ml, respectively; p < 0.001). In multivariate analysis, the severity of preeclampsia was correlated with LFABP level [unadjusted odds ratio (95% confidence interval), 1.008 (1.003-1.012), p < 0.001 and LDH 1.063 (1.029-1.099), p < 0.001].
Maternal serum LFABP level appears to be correlated with the severity of the preeclampsia and can be used to confirm the diagnosis.
本研究旨在评估子痫前期女性的肝脏脂肪酸结合蛋白（LFABP）水平。
对90名孕妇进行了一项病例对照研究，这些孕妇被分为以下三组：正常妊娠组（n = 30）、轻度 - 中度子痫前期组（n = 30）和重度子痫前期组（n = 30）。正常孕妇在产前检查门诊时采集母血样本，子痫前期女性在确诊时采集。采用定量夹心酶免疫测定技术测量血清LFABP水平。
重度和轻度 - 中度子痫前期组的血清LFABP水平显著高于正常妊娠组（分别为1,709.90 ± 94.82、1,614.93 ± 118.22和1,532.36 ± 140.98 pg/ml；p < 0.001）。在多变量分析中，子痫前期的严重程度与LFABP水平相关[未调整比值比（95%置信区间），1.008（1.003 - 1.012），p < 0.001，乳酸脱氢酶为1.063（1.029 - 1.099），p < 0.001]。
母血清LFABP水平似乎与子痫前期的严重程度相关，可用于确诊。
