Sieb J P, Mattle H, Pirovino M
Neurologische Universitätsklinik, Inselspital, Bern.
Dtsch Med Wochenschr. 1989 Mar 17;114(11):417-9. doi: 10.1055/s-2008-1066611.
Between 1983 and 1987 three patients (mean age 31 years) with neurofibrosarcoma were seen among 22 with von Recklinghausen neurofibromatosis (NF-1) at the Department of Neurology, University of Berne, Switzerland. There was an average interval of 14 months between onset of symptoms and treatment. The first presenting sign was a rapidly enlarging mass or unusual persistent pain. The occurrence of either sign, in the known presence of NF-1, should lead to immediate neuroradiological investigation. The mean survival time of the three patients was 37 months. Only early diagnosis provides any chance of curative treatment.
1983年至1987年间，瑞士伯尔尼大学神经病学系在22例患有冯·雷克林豪森神经纤维瘤病（NF-1）的患者中发现了3例神经纤维肉瘤患者（平均年龄31岁）。症状出现与治疗之间的平均间隔为14个月。首发症状为迅速增大的肿块或异常持续疼痛。在已知患有NF-1的情况下，出现上述任何一种症状都应立即进行神经放射学检查。这3例患者的平均生存时间为37个月。只有早期诊断才有治愈的机会。
