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孟加拉国吉大港查塔姆玛奥希舒综合医院缺铁性贫血患儿血液学参数研究

Study of Hematological Parameters in Children Suffering from Iron Deficiency Anaemia in Chattagram Maa-o-Shishu General Hospital, Chittagong, Bangladesh.

作者信息

Mohammed Mujib Abu Syed, Mohammad Mahmud Abu Sayeed, Halder Milton, Monirul Hasan Chowdhury Mohammad

机构信息

Industrial Microbiology Research Division, Bangladesh Council of Scientific and Industrial Research, Chittagong 4220, Bangladesh.

Department of Biochemistry and Molecular Biology, University of Chittagong, Chittagong 4331, Bangladesh.

出版信息

Anemia. 2014;2014:503981. doi: 10.1155/2014/503981. Epub 2014 Oct 21.

Abstract

A total of 150 (30.61%) anemic patients out of 490 patients diagnosed to have iron deficiency anemia (IDA) have been selected for the first time in Bangladesh. For detailed study, blood samples from 150 anemic patients along with 25 controls were analyzed. Analysis of variance showed significant P value between mean platelet volume (MPV) in females (8.08 μm(3)) and males (7.59 μm(3)) (P < 0.05) in iron deficiency anemia patients. Besides, the value of white blood cells (WBC) in males (10946.08/cmm) was significantly higher than in females (9470.833/cmm) (P < 0.05). The significant correlation was observed among hemoglobin levels with hematocrits, hemoglobin with RBC, RBC with hematocrits, and MCV with MCH as well as MCH with MCHC. However, the negative correlation was observed between the hematological variables neutrophils and lymphocytes (r = -0.989). The common complaints we have found in the survey were weight loss 73.33%, attention problem 68%, dyspepsia 65%, decrease of appetite 72%, weakness 68%, diarrhea 65%, and headache 55% among IDA patients. ANOVA showed significant statistical difference in all the hematological and biochemical parameters. Analysis of variance test between anemias with only one of three biochemical parameters decreased and control showed that this group does not have iron deficiency.

摘要

在孟加拉国,首次从490名被诊断为缺铁性贫血(IDA)的患者中选取了150名(30.61%)贫血患者。为进行详细研究,对150名贫血患者以及25名对照者的血样进行了分析。方差分析显示,缺铁性贫血患者中女性的平均血小板体积(MPV)(8.08μm³)与男性(7.59μm³)之间的P值具有统计学意义(P<0.05)。此外,男性的白细胞(WBC)值(10946.08/cmm)显著高于女性(9470.833/cmm)(P<0.05)。观察到血红蛋白水平与血细胞比容、血红蛋白与红细胞、红细胞与血细胞比容、平均红细胞体积(MCV)与平均红细胞血红蛋白含量(MCH)以及MCH与平均红细胞血红蛋白浓度(MCHC)之间存在显著相关性。然而,血液学变量中性粒细胞和淋巴细胞之间呈负相关(r = -0.989)。我们在调查中发现,IDA患者常见的主诉包括体重减轻(73.33%)、注意力问题(68%)、消化不良(65%)、食欲减退(72%)、虚弱(68%)、腹泻(65%)和头痛(55%))。方差分析显示所有血液学和生化参数均存在显著统计学差异。仅三项生化参数之一降低的贫血患者与对照组之间的方差分析表明,该组不存在缺铁情况。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ae97/4221982/05d9b1458d82/ANEMIA2014-503981.001.jpg

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