表皮生长因子受体（EGFR）R521K多态性与癌症风险关系的Meta分析
A Meta-Analysis on the Relations between EGFR R521K Polymorphism and Risk of Cancer.
作者信息
Wang Yinsheng, Zha Lidan, Liao Dan, Li Xiaozhi
机构信息
Department of Stomatology, The First Affiliated Hospital of Chongqing Medical University, Chongqing Medical University, No. 1 Yixueyuan Road, Chongqing 400016, China.
出版信息
Int J Genomics. 2014;2014:312102. doi: 10.1155/2014/312102. Epub 2014 Oct 21.
The EGFR R521K polymorphism has been shown to reduce the activity of EGFR; however, the association between EGFR R521K polymorphism and the risk of cancer remains inconclusive; therefore we performed a meta-analysis to evaluate the relationship between EGFR R521K polymorphism and susceptibility to cancer. Our results suggest that the EGFR R521K polymorphism is not associated with risk of cancer, but the different chemosensitivity to anticancer drugs may need further investigation.
表皮生长因子受体（EGFR）R521K多态性已被证明会降低EGFR的活性；然而，EGFR R521K多态性与癌症风险之间的关联仍无定论；因此，我们进行了一项荟萃分析，以评估EGFR R521K多态性与癌症易感性之间的关系。我们的结果表明，EGFR R521K多态性与癌症风险无关，但对抗癌药物的不同化学敏感性可能需要进一步研究。
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