• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

表皮生长因子受体（EGFR）R521K多态性与癌症风险关系的Meta分析

A Meta-Analysis on the Relations between EGFR R521K Polymorphism and Risk of Cancer.

作者信息

Wang Yinsheng, Zha Lidan, Liao Dan, Li Xiaozhi

机构信息

Department of Stomatology, The First Affiliated Hospital of Chongqing Medical University, Chongqing Medical University, No. 1 Yixueyuan Road, Chongqing 400016, China.

出版信息

Int J Genomics. 2014;2014:312102. doi: 10.1155/2014/312102. Epub 2014 Oct 21.

DOI:10.1155/2014/312102
PMID:25401099
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4221867/
Abstract

The EGFR R521K polymorphism has been shown to reduce the activity of EGFR; however, the association between EGFR R521K polymorphism and the risk of cancer remains inconclusive; therefore we performed a meta-analysis to evaluate the relationship between EGFR R521K polymorphism and susceptibility to cancer. Our results suggest that the EGFR R521K polymorphism is not associated with risk of cancer, but the different chemosensitivity to anticancer drugs may need further investigation.

摘要

表皮生长因子受体（EGFR）R521K多态性已被证明会降低EGFR的活性；然而，EGFR R521K多态性与癌症风险之间的关联仍无定论；因此，我们进行了一项荟萃分析，以评估EGFR R521K多态性与癌症易感性之间的关系。我们的结果表明，EGFR R521K多态性与癌症风险无关，但对抗癌药物的不同化学敏感性可能需要进一步研究。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b50b/4221867/fe9022fc7388/IJG2014-312102.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b50b/4221867/fe9022fc7388/IJG2014-312102.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b50b/4221867/fe9022fc7388/IJG2014-312102.001.jpg

相似文献

1
A Meta-Analysis on the Relations between EGFR R521K Polymorphism and Risk of Cancer.表皮生长因子受体（EGFR）R521K多态性与癌症风险关系的Meta分析
Int J Genomics. 2014;2014:312102. doi: 10.1155/2014/312102. Epub 2014 Oct 21.
2
The Relations between EGFR R521K Polymorphism and Risk of Cancer: Need for Clarification of Data in a Recent Meta-Analysis.表皮生长因子受体（EGFR）R521K多态性与癌症风险之间的关系：近期一项荟萃分析中数据需进一步阐明
Int J Genomics. 2015;2015:597413. doi: 10.1155/2015/597413. Epub 2015 Mar 19.
3
The EGFR R521K polymorphism influences the risk to develop colorectal cancer.EGFR R521K 多态性影响结直肠癌的发病风险。
Cancer Biomark. 2010;8(2):61-5. doi: 10.3233/DMA-2011-0826.
4
Association of epidermal growth factor receptor polymorphism, skin toxicity, and outcome in patients with squamous cell carcinoma of the head and neck receiving cetuximab-docetaxel treatment.表皮生长因子受体多态性与皮肤毒性及头颈部鳞状细胞癌患者接受西妥昔单抗-多烯紫杉醇治疗结局的相关性。
Clin Cancer Res. 2010 Jan 1;16(1):304-10. doi: 10.1158/1078-0432.CCR-09-1928. Epub 2009 Dec 22.
5
Analysis of the polymorphisms EGFR-r521K and ERBB2-I655V in Mexican patients with gastric cancer and premalignant gastric lesions.墨西哥胃癌及癌前胃部病变患者中EGFR-r521K和ERBB2-I655V多态性分析
Rev Invest Clin. 2013 Mar-Apr;65(2):150-5.
6
Epidermal growth factor receptor expression in gastric tumors and its relationship with the germline polymorphisms - 216 G>T, -191 C>A, (CA) n IVS1, and R521K.表皮生长因子受体在胃肿瘤中的表达及其与种系多态性-216 G>T、-191 C>A、(CA)n IVS1和R521K的关系。
Indian J Cancer. 2016 Jul-Sep;53(3):345-348. doi: 10.4103/0019-509X.200648.
7
EGF and EGFR genetic polymorphisms predict prognosis in locally advanced pharyngolaryngeal squamous cell carcinoma patients receiving postoperative concurrent chemoradiotherapy.表皮生长因子（EGF）和表皮生长因子受体（EGFR）基因多态性可预测接受术后同步放化疗的局部晚期咽喉鳞状细胞癌患者的预后。
Onco Targets Ther. 2014 Nov 28;7:2197-204. doi: 10.2147/OTT.S70188. eCollection 2014.
8
Association between EGFR gene polymorphisms, skin rash and response to anti-EGFR therapy in metastatic colorectal cancer patients.转移性结直肠癌患者中表皮生长因子受体（EGFR）基因多态性、皮疹与抗EGFR治疗反应之间的关联
Exp Dermatol. 2014 Oct;23(10):751-3. doi: 10.1111/exd.12510.
9
EGFR R521K predicts cetuximab response in KRAS wild-type patients.表皮生长因子受体（EGFR）R521K突变可预测KRAS基因野生型患者对西妥昔单抗的反应。
Pharmacogenomics. 2012 May;13(7):746.
10
Association of epidermal growth factor receptor (EGFR) gene polymorphism with lung cancer risk: a systematic review.表皮生长因子受体（EGFR）基因多态性与肺癌风险的关联：一项系统综述。
J Recept Signal Transduct Res. 2014 Oct;34(5):333-4. doi: 10.3109/10799893.2014.885052. Epub 2014 Feb 4.

引用本文的文献

1
Exploring the mutational spectrum of key kinase genes PIK3CA, BRAF, EGFR, ALK and ROS1 in oral squamous cell carcinoma.探索口腔鳞状细胞癌中关键激酶基因PIK3CA、BRAF、EGFR、ALK和ROS1的突变谱。
BMC Cancer. 2025 Aug 18;25(1):1333. doi: 10.1186/s12885-025-14609-8.
2
Experimental System Design and Modelling of EGFR Extracellular Domain and Its Mutant Binding to Antibody Interacting Partner.表皮生长因子受体（EGFR）胞外结构域及其突变体与抗体相互作用伴侣结合的实验系统设计与建模
Int J Mol Sci. 2025 Apr 11;26(8):3594. doi: 10.3390/ijms26083594.
3
Meta-analysis of gene polymorphisms and lung cancer risk.

本文引用的文献

1
Evolutionary mechanism unifies the hallmarks of cancer.进化机制统一了癌症的特征。
Int J Cancer. 2015 May 1;136(9):2012-21. doi: 10.1002/ijc.29031. Epub 2014 Jun 30.
2
Epidermal growth factor receptor gene polymorphisms are associated with prognostic features of breast cancer.表皮生长因子受体基因多态性与乳腺癌的预后特征有关。
BMC Cancer. 2014 Mar 14;14:190. doi: 10.1186/1471-2407-14-190.
3
Therapeutic resistance in cancer: microRNA regulation of EGFR signaling networks.癌症中的治疗抗性：微小RNA对表皮生长因子受体信号网络的调控
基因多态性与肺癌风险的荟萃分析。
Int J Immunopathol Pharmacol. 2025 Jan-Dec;39:3946320251316731. doi: 10.1177/03946320251316731.
4
Mutations in Head and Neck Squamous Cell Carcinoma.头颈部鳞状细胞癌的突变。
Int J Mol Sci. 2022 Mar 30;23(7):3818. doi: 10.3390/ijms23073818.
5
The Investigation of Associations between rs1042522, rs2032809, rs9344, rs2227983 Polymorphisms and Breast Cancer Phenotype and Prognosis.rs1042522、rs2032809、rs9344、rs2227983多态性与乳腺癌表型及预后之间的关联研究
Diagnostics (Basel). 2021 Aug 5;11(8):1419. doi: 10.3390/diagnostics11081419.
6
Role of EGFR gene polymorphisms in oral squamous cell carcinoma patients of Southeast Iran: A case-control study.表皮生长因子受体基因多态性在伊朗东南部口腔鳞状细胞癌患者中的作用：一项病例对照研究。
Caspian J Intern Med. 2020 Fall;11(4):391-397. doi: 10.22088/cjim.11.4.391.
7
Stapled EGFR peptide reduces inflammatory breast cancer and inhibits additional HER-driven models of cancer.订书钉 EGFR 肽可减少炎性乳腺癌，并抑制其他 HER 驱动的癌症模型。
J Transl Med. 2019 Jun 18;17(1):201. doi: 10.1186/s12967-019-1939-7.
8
The Association between Epidermal Growth Factor Receptor () Gene Polymorphisms and Lung Cancer Risk.表皮生长因子受体（）基因多态性与肺癌风险的关联。
Biomolecules. 2018 Jul 13;8(3):53. doi: 10.3390/biom8030053.
9
Evaluation of the EGFR polymorphism R497K in two cohorts of neoadjuvantly treated breast cancer patients.在两组接受新辅助治疗的乳腺癌患者中评估表皮生长因子受体（EGFR）多态性R497K。
PLoS One. 2017 Dec 21;12(12):e0189750. doi: 10.1371/journal.pone.0189750. eCollection 2017.
10
The Relations between EGFR R521K Polymorphism and Risk of Cancer: Need for Clarification of Data in a Recent Meta-Analysis.表皮生长因子受体（EGFR）R521K多态性与癌症风险之间的关系：近期一项荟萃分析中数据需进一步阐明
Int J Genomics. 2015;2015:597413. doi: 10.1155/2015/597413. Epub 2015 Mar 19.
Cancer Biol Med. 2013 Dec;10(4):192-205. doi: 10.7497/j.issn.2095-3941.2013.04.003.
4
The quest to overcome resistance to EGFR-targeted therapies in cancer.克服癌症中表皮生长因子受体靶向治疗耐药性的探索。
Nat Med. 2013 Nov;19(11):1389-400. doi: 10.1038/nm.3388. Epub 2013 Nov 7.
5
Molecular biology of lung cancer.肺癌的分子生物学
J Thorac Dis. 2013 Oct;5 Suppl 5(Suppl 5):S479-90. doi: 10.3978/j.issn.2072-1439.2013.08.03.
6
The polymorphism of EGFR 142285G > A exerts no risk effect on breast cancer.表皮生长因子受体（EGFR）142285G > A的多态性对乳腺癌没有风险影响。
Tumour Biol. 2014 Mar;35(3):2383-9. doi: 10.1007/s13277-013-1315-9. Epub 2013 Oct 28.
7
Biomarkers of drugs targeting HER-family signalling in cancer.针对癌症中 HER 家族信号的药物的生物标志物。
J Pathol. 2014 Jan;232(2):219-29. doi: 10.1002/path.4269.
8
Analysis of the polymorphisms EGFR-r521K and ERBB2-I655V in Mexican patients with gastric cancer and premalignant gastric lesions.墨西哥胃癌及癌前胃部病变患者中EGFR-r521K和ERBB2-I655V多态性分析
Rev Invest Clin. 2013 Mar-Apr;65(2):150-5.
9
Associations between genetic polymorphisms of epidermal growth factor receptor (EGFR) and survival of colorectal cancer (CRC) patients treated with 5-fluorouracil-based chemotherapy.表皮生长因子受体（EGFR）基因多态性与接受 5-氟尿嘧啶为基础化疗的结直肠癌（CRC）患者生存的相关性。
Ann Surg Oncol. 2013 Dec;20 Suppl 3:S599-606. doi: 10.1245/s10434-013-3069-4. Epub 2013 Jun 26.
10
Association of epidermal growth factor and epidermal growth factor receptor polymorphisms with the risk of hepatitis B virus-related hepatocellular carcinoma in the population of North China.华北人群中表皮生长因子及表皮生长因子受体基因多态性与乙型肝炎病毒相关肝细胞癌风险的关联
Genet Test Mol Biomarkers. 2013 Aug;17(8):595-600. doi: 10.1089/gtmb.2013.0031. Epub 2013 Jun 22.