Torres-Jasso Juan Heriberto, Bustos-Carpinteyro Andrea Rebeca, Marín María Eugenia, Santiago Ernesto, Leoner Carlos, Flores-Luna Lourdes, Torres Javier, Sánchez-Lopez Josefina Yoaly
Genética Humana CUCS, Universidad de Guadalajara.
Rev Invest Clin. 2013 Mar-Apr;65(2):150-5.
The proto-oncogenes epidermal growth factor receptor (EGFR) and erythroblastic leukemia viral oncogene homolog 2 (ERBB2), are involved in the development of diverse malignant tumors, including gastric cancer. We analyzed the association of SNPs EGFR-R521K and ERBB2-I655V with gastric cancer and premalignant gastric lesions in Mexican patients. Through restriction fragment length polymorphisms, we analyze both SNPs in the DNA from 155 patients with gastric cancer and premalignant gastric lesions, 121 controls, and 103 people from the Mexican general population. The frequencies of both SNPs did not differ significantly between any of the groups (chi2 p = NS); Odds ratio analysis showed that the alleles EGFR-521K and ERBB2-655V were not related to gastric cancer or premalignant gastric lesions in the Mexican population. Our data suggest that the EGFR-R521K and ERBB2-I655V polymorphisms are not suitable as markers for identifying individuals with a higher risk for developing gastric cancer in our population.
原癌基因表皮生长因子受体（EGFR）和成红细胞白血病病毒癌基因同源物2（ERBB2）参与包括胃癌在内的多种恶性肿瘤的发生发展。我们分析了单核苷酸多态性（SNPs）EGFR-R521K和ERBB2-I655V与墨西哥患者胃癌及癌前胃部病变的相关性。通过限制性片段长度多态性分析，我们检测了155例胃癌及癌前胃部病变患者、121例对照以及103名墨西哥普通人群的DNA中的这两个SNPs。两组间这两个SNPs的频率均无显著差异（卡方检验p值无统计学意义）；优势比分析表明，等位基因EGFR-521K和ERBB2-655V与墨西哥人群的胃癌或癌前胃部病变无关。我们的数据表明，EGFR-R521K和ERBB2-I655V多态性不适用于作为识别我们人群中胃癌发生风险较高个体的标志物。
