Wilusz Jeremy E, Wilusz Jeffrey
Department of Biochemistry and Biophysics, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania 19104, USA;
Department of Microbiology, Immunology, and Pathology, Colorado State University, Fort Collins, Colorado 80523, USA
Genes Dev. 2014 Nov 15;28(22):2447-9. doi: 10.1101/gad.254193.114.
Production of multiple functional RNAs from a single primary transcript is an extremely efficient use of genetic information, although it complicates the ability of the cell to independently regulate the production of each RNA. For the case of small nucleolar RNAs (snoRNAs) encoded within introns of mRNA genes, Lykke-Andersen and colleagues (pp. 2498-2517) demonstrated that alternative splicing and the SMG6 endonuclease of the nonsense-mediated RNA decay pathway are key regulators that control which RNAs accumulate.
从单个初级转录本产生多种功能性RNA是对遗传信息的一种极其有效的利用，尽管这使细胞独立调节每种RNA产生的能力变得复杂。对于mRNA基因内含子中编码的小核仁RNA（snoRNA）而言，Lykke-Andersen及其同事（第2498 - 2517页）证明，可变剪接和无义介导的RNA降解途径中的SMG6核酸内切酶是控制哪些RNA积累的关键调节因子。
