Graversen Veronica Kon, Chavala Sai H
Department of Surgery, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Department of Ophthalmology, University of North Carolina, 5151 Bioinformatics Building, CB #7040, Chapel Hill, NC, 27599-7040, USA.
Methods Mol Biol. 2016;1357:395-401. doi: 10.1007/7651_2014_148.
Reprogramming fibroblasts into induced pluripotent stem cells (iPSC) remains a promising technique for cell replacement therapy. Diverse populations of somatic cells have been examined for their reprogramming potential. Recently, ocular ciliary body epithelial cells (CECs) have been reprogrammed with high reprogramming efficiency and single transcription factor reprogramming, making them an exciting candidate for cellular reprogramming strategies.
将成纤维细胞重编程为诱导多能干细胞（iPSC）仍然是细胞替代疗法中一项很有前景的技术。人们已经对多种体细胞群体的重编程潜力进行了研究。最近，眼睫状体上皮细胞（CECs）已被高效重编程，并且可通过单一转录因子进行重编程，这使其成为细胞重编程策略中一个令人兴奋的候选对象。
