Terskikh I I, Abramova L N, Savostina N S, Gromashevskiĭ V L, L'vov D K
Med Parazitol (Mosk). 1989 Jan-Feb(1):71-4.
The paper presents the results of a comparative experimental study of pathoginicity of the Karshi virus (Flaviviridae) isolated from Ornithodoros papillipes ticks collected in Uzbekistan, for white mice, Syrian hamsters and green monkeys using various administration routes. Localization and types of lesions (brain, lungs, liver, spleen, kidneys) as well as the presence of viruses in blood and body organs are described basing on histological and virusological studies. Specific antibodies are found in monkeys' blood sera. Hematogenic route of distribution of the virus and its pantropical character are revealed. White mice are found to be the most sensitive model.
本文介绍了从乌兹别克斯坦采集的乳突钝缘蜱中分离出的卡尔希病毒（黄病毒科），通过不同给药途径对小白鼠、叙利亚仓鼠和绿猴致病性的比较实验研究结果。基于组织学和病毒学研究，描述了病变的定位和类型（脑、肺、肝、脾、肾）以及血液和身体器官中病毒的存在情况。在猴子的血清中发现了特异性抗体。揭示了病毒的血源性传播途径及其泛热带特征。发现小白鼠是最敏感的模型。
