Borges Gisely T, Vêncio Eneida F, Vêncio Ricardo Z N, Vessella Robert L, Ware Carol B, Liu Alvin Y
School of Pharmacology, Federal University of Goiás, Goiânia, Brazil,
Curr Urol Rep. 2015 Jan;16(1):468. doi: 10.1007/s11934-014-0468-4.
Prostate cancer progression is characterized by tumor dedifferentiation. Cancer cells of less differentiated tumors have a gene expression/transcriptome more similar to that of stem cells. In dedifferentiation, cancer cells may follow a specific program of gene expression changes to a stem-like state. In order to treat cancer effectively, the stem-like cancer cells and cancer differentiation pathway need to be identified and studied. Due to the very low abundance of stem-like cancer cells, their isolation from fresh human tumors is technically challenging. Induced pluripotent stem cell technology can reprogram differentiated cells into stem-like, and this may be a tool to generate sufficient stem-like cancer cells.
前列腺癌进展的特征是肿瘤去分化。低分化肿瘤的癌细胞具有与干细胞更相似的基因表达/转录组。在去分化过程中，癌细胞可能遵循特定的基因表达变化程序转变为干细胞样状态。为了有效治疗癌症，需要识别和研究干细胞样癌细胞及癌症分化途径。由于干细胞样癌细胞的丰度极低，从新鲜人类肿瘤中分离它们在技术上具有挑战性。诱导多能干细胞技术可以将分化细胞重编程为干细胞样细胞，这可能是产生足够数量干细胞样癌细胞的一种工具。
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