Center for iPS Cell Research and Application, Kyoto University, Kyoto, 606-8507, Japan.
Development. 2013 Jun;140(12):2457-61. doi: 10.1242/dev.092551.
Differentiated cells can be reprogrammed to pluripotency and other cell fates by treatment with defined factors. The discovery of induced pluripotent stem cells (iPSCs) has opened up unprecedented opportunities in the pharmaceutical industry, in the clinic and in laboratories. In particular, the medical applications of human iPSCs in disease modeling and stem cell therapy have been progressing rapidly. The ability to induce cell fate conversion is attractive not only for these applications, but also for basic research fields, such as development, cancer, epigenetics and aging.
分化细胞可通过特定因子的处理重编程为多能性和其他细胞命运。诱导多能干细胞（iPSC）的发现为制药业、临床和实验室带来了前所未有的机遇。特别是，人类 iPSC 在疾病建模和干细胞治疗方面的医学应用正在迅速发展。诱导细胞命运转换的能力不仅对这些应用具有吸引力，而且对发育、癌症、表观遗传学和衰老等基础研究领域也具有吸引力。
