Ahmed Najia, Iftikhar Nadia, Bashir Uzma, Rizvi Syed Dilawar Abbas, Sheikh Zafar Iqbal, Manzur Amir
Department of Dermatology, Combined Military Hospital, Multan.
Department of Dermatology, Military Hospital, Rawalpindi.
J Coll Physicians Surg Pak. 2014 Nov;24(11):802-5.
To determine the efficacy of clarithromycin in the treatment of Pityriasis Rosea (PR).
Double blind randomized controlled trial.
Dermatology OPD, Military Hospital, Rawalpindi, from July 2008 to July 2009.
Patients aged above 10 years, diagnosed with PR, were randomly assigned to two groups of 30 each to receive either clarithromycin or similar-looking placebo for one week. Neither the patient nor the treating physician knew to which group the patient belonged. Patients were assessed at 1, 2, 4 and 6 weeks after presentation and compared for complete, partial or no response.
Among the 60 patients, no significant difference was found between the two groups at 2 weeks after presentation (p = 0.598). In the placebo group, complete response was seen in 20 (66.7%), partial response in 3 (10.0%) while no response was seen in 7 (23.3%). In clarithromycin group, there was complete response in 23 (76.7%), partial response in 3 (10.0%) and no response in 4 (13.3%) patients.
Clarithromycin is not effective in treatment of pityriasis rosea.
确定克拉霉素治疗玫瑰糠疹（PR）的疗效。
双盲随机对照试验。
2008年7月至2009年7月，拉瓦尔品第军事医院皮肤科门诊。
年龄在10岁以上、诊断为玫瑰糠疹的患者被随机分为两组，每组30人，分别接受克拉霉素或外观相似的安慰剂治疗一周。患者和治疗医生均不知道患者所属组别。在就诊后1、2、4和6周对患者进行评估，并比较完全缓解、部分缓解或无缓解情况。
60例患者中，就诊后2周两组间无显著差异（p = 0.598）。安慰剂组中，20例（66.7%）完全缓解，3例（10.0%）部分缓解，7例（23.3%）无缓解。克拉霉素组中，23例（76.7%）完全缓解，3例（10.0%）部分缓解，4例（13.3%）无缓解。
克拉霉素对玫瑰糠疹治疗无效。
