Abbas Raana, Abbas Hafiz Ghulam, Shahid Abubaker, Chand Sohail, Nawaz Sara
Institute of Nuclear Medicine and Oncology (INMOL), Lahore.
College of Statistical and Actuarial Sciences, University of the Punjab, Lahore.
J Coll Physicians Surg Pak. 2014 Nov;24(11):806-9.
To establish reference intervals for Free Triiodothyronine (FT3) and Free Thyroxine (FT4) in euthyroid subjects and to assess the effect of age and gender on FT3 and FT4.
Cross-sectional, analytical study.
Institute of Nuclear Medicine and Oncology (INMOL), Lahore, from January 2009 to April 2011.
FT3 and FT4 were measured in 852 euthyroid patients. Those with previous thyroid surgery, on thyroidrelated medication and severe non-thyroid illness were excluded.
There were 215 males and 637 females with mean age of 46 years. The reference intervals, revealed by this study, for FT3 and FT4 were 2.80 - 5.39 pmol/L and 11.9 - 22.2 pmol/L respectively. The mean difference between gender groups and age groups was found statistically significant for FT3 (gender: p < 0.001; age: p < 0.001) but statistically insignificant for FT4 (gender: p=0.147; age: p=0.201).
There was no effect of gender and age on FT3 and FT4. The age with serum FT3 and FT4 significantly negatively correlated but this correlation was stronger for FT3 as compared to FT4 levels. Reference intervals of FT3 and FT4 for male (2.99 - 5.63 pmol/L, 12.3 - 22.6 pmol/L) and female (2.77 - 5.29 pmol/L, 11.7 - 22.1 pmol/L) respectively are suggested.
建立甲状腺功能正常受试者的游离三碘甲状腺原氨酸（FT3）和游离甲状腺素（FT4）的参考区间，并评估年龄和性别对FT3和FT4的影响。
横断面分析研究。
拉合尔核医学与肿瘤学研究所（INMOL），2009年1月至2011年4月。
对852例甲状腺功能正常的患者进行FT3和FT4检测。排除既往有甲状腺手术史、正在服用甲状腺相关药物以及患有严重非甲状腺疾病的患者。
共有215名男性和637名女性，平均年龄为46岁。本研究得出的FT3和FT4的参考区间分别为2.80 - 5.39 pmol/L和11.9 - 22.2 pmol/L。FT3在性别组和年龄组之间的平均差异具有统计学意义（性别：p < 0.001；年龄：p < 0.001），但FT4在性别组和年龄组之间的平均差异无统计学意义（性别：p = 0.147；年龄：p = 0.201）。
性别和年龄对FT3和FT4没有影响。年龄与血清FT3和FT4呈显著负相关，但与FT4水平相比，FT3的这种相关性更强。建议男性FT3和FT4的参考区间分别为（2.99 - 5.63 pmol/L，12.3 - 22.6 pmol/L），女性为（2.77 - 5.29 pmol/L，11.7 - 22.1 pmol/L）。
