Cascales C, Boscá L, Martín-Sanz P, Brindley D N, Cascales M
Instituto de Bioquímica, Facultad de Farmacia, Madrid, Spain.
Toxicol Lett. 1989 Apr;47(1):9-16. doi: 10.1016/0378-4274(89)90081-7.
The translocation of phosphatidate phosphohydrolase induced by oleate was higher (two-fold) in liver homogenates obtained from long-term thioacetamide-treated rats than from control rats. These differences between thioacetamide-treated and control livers were noticeably higher (four-fold) in the presence of physiological concentrations of salt (0.15 M KCl). In homogenates from control rats, there was a lack of response when physiological concentrations of the salt were present. The enhanced response to translocate phosphatidate phosphohydrolase activity in liver homogenates from thioacetamide-treated rats was due to an increased binding ability of microsomal membranes.
由油酸诱导的磷脂酸磷酸水解酶的易位，在长期硫代乙酰胺处理的大鼠肝脏匀浆中比对照大鼠的肝脏匀浆更高（两倍）。在生理浓度的盐（0.15M KCl）存在下，硫代乙酰胺处理的肝脏与对照肝脏之间的这些差异明显更高（四倍）。在对照大鼠的匀浆中，当存在生理浓度的盐时没有反应。硫代乙酰胺处理的大鼠肝脏匀浆中磷脂酸磷酸水解酶活性易位的增强反应是由于微粒体膜结合能力的增加。
