Harper Benjamin W J, Aldrich-Wright Janice R
Nanoscale Organisation and Dynamics Group, School of Science and Health, University of Western Sydney, Locked Bag 1797, Penrith South DC, 2751, NSW, Australia.
Dalton Trans. 2015 Jan 7;44(1):87-96. doi: 10.1039/c4dt02773f.
Dinuclear (2,2':6',2''-terpyridine)platinum(II) (PtTerpy) complexes were synthesised by tethering either thiol or pyridine based linkers. All intermediates and resulting complexes were characterised using a combination of (1)H and (195)Pt NMR, two-dimensional (1)H correlation spectroscopy (NOSY/COSY), two-dimensional (1)H/(195)Pt heteronuclear multiple bond correlation spectroscopy (HMQC), elemental analysis and electrospray ionisation mass spectrometry (ESI-MS). The cytotoxicity of the complexes was determined against human A2780 ovarian carcinoma cells and its cisplatin-resistant sub-line A2780cis, as well as L1210 murine leukemia cells.
通过连接基于硫醇或吡啶的连接体合成了双核（2,2':6',2''-三联吡啶）铂（II）（PtTerpy）配合物。所有中间体和所得配合物均通过¹H和¹⁹⁵Pt核磁共振、二维¹H相关光谱（核Overhauser效应光谱/化学位移相关光谱）、二维¹H/¹⁹⁵Pt异核多键相关光谱、元素分析和电喷雾电离质谱进行表征。测定了这些配合物对人A2780卵巢癌细胞及其顺铂耐药亚系A2780cis以及L1210小鼠白血病细胞的细胞毒性。
