Ali Akbari Ghavimi Soheila, Ebrahimzadeh Mohammad H, Solati-Hashjin Mehran, Abu Osman Noor Azuan
Department of Biomedical Engineering, Faculty of Engineering, University of Malaya, 50603, Kuala Lumpur, Malaysia.
Orthopedic Research Center, Mashhad University of Medical Science, Mashhad, Iran.
J Biomed Mater Res A. 2015 Jul;103(7):2482-98. doi: 10.1002/jbm.a.35371. Epub 2014 Dec 3.
Interests in the use of biodegradable polymers as biomaterials have grown. Among the different polymeric composites currently available, the blend of starch and polycaprolactone (PCL) has received the most attention since the 1980s. Novamont is the first company that manufactured a PCL/starch (SPCL) composite under the trademark Mater-Bi®. The properties of PCL (a synthetic, hydrophobic, flexible, expensive polymer with a low degradation rate) and starch (a natural, hydrophilic, stiff, abundant polymer with a high degradation rate) blends are interesting because of the composite components have completely different structures and characteristics. PCL can adjust humidity sensitivity of starch as a biomaterial; while starch can enhance the low biodegradation rate of PCL. Thus, by appropriate blending, SPCL can overcome important limitations of both PCL and starch components and promote controllable behavior in terms of mechanical properties and degradation which make it suitable for many biomedical applications. This article reviewed the different fabrication and modification methods of the SPCL composite; different properties such as structural, physical, and chemical as well as degradation behavior; and different applications as biomaterials.
对使用可生物降解聚合物作为生物材料的兴趣与日俱增。在目前可用的不同聚合物复合材料中，自20世纪80年代以来，淀粉与聚己内酯（PCL）的共混物受到了最多关注。诺瓦蒙特公司是第一家以Mater-Bi®商标生产PCL/淀粉（SPCL）复合材料的公司。PCL（一种合成的、疏水的、柔性的、昂贵的且降解速率低的聚合物）与淀粉（一种天然的、亲水的、刚性的、丰富的且降解速率高的聚合物）共混物的性能很有趣，因为复合材料的组分具有完全不同的结构和特性。PCL作为生物材料可调节淀粉的湿度敏感性；而淀粉可提高PCL低的生物降解速率。因此，通过适当共混，SPCL可克服PCL和淀粉组分的重要局限性，并在机械性能和降解方面促进可控行为，这使其适用于许多生物医学应用。本文综述了SPCL复合材料的不同制备和改性方法；不同性能，如结构、物理、化学性能以及降解行为；以及作为生物材料的不同应用。
