Klein C P, Patka P, den Hollander W
Department of Biomaterial Sciences, ACTA, Free University Hospital, Amsterdam, The Netherlands.
Biomaterials. 1989 Jan;10(1):59-62. doi: 10.1016/0142-9612(89)90011-2.
This study examines the biodegradation behaviour of calcium phosphate macroporous bioceramics consisting of hydroxylapatite or beta-whitlockite implants. The implantations were performed in hard tissue of femora and muscular tissue of dogs for periods of 6 and 12 month. With microradiography and light microscopy, respectively, of ground and thin sections it was shown that hydroxylapatite remained unchanged and beta-whitlockite degraded within 6 month in bone tissue. In the muscular tissue, the biodegradation of beta-whitlockite was slower. In addition, beta-whitlockite gave rise to a cellular response of lymphocytes and plasma cells rather than hydroxylapatite in the soft tissue region. For tissue response hydroxylapatite is more suitable as an implant material than beta-whitlockite.
本研究考察了由羟基磷灰石或β-白磷钙矿植入物组成的磷酸钙大孔生物陶瓷的生物降解行为。将植入物分别植入狗的股骨硬组织和肌肉组织中，为期6个月和12个月。通过对磨片和薄片分别进行显微放射照相和光学显微镜观察，结果表明，羟基磷灰石在骨组织中6个月内保持不变，而β-白磷钙矿发生降解。在肌肉组织中，β-白磷钙矿的生物降解较慢。此外，在软组织区域，β-白磷钙矿引发了淋巴细胞和浆细胞的细胞反应，而羟基磷灰石则没有。对于组织反应而言，羟基磷灰石比β-白磷钙矿更适合作为植入材料。
Zotero 插件