糖尿病：脂肪中的益处。
Diabetes: The good in fat.
作者信息
Muoio Deborah M, Newgard Christopher B
机构信息
Sarah W. Stedman Nutrition and Metabolism Center and Duke Molecular Physiology Institute, and the Departments of Pharmacology and Cancer Biology and Medicine, Duke University Medical Center, Durham, North Carolina 27701, USA.
出版信息
Nature. 2014 Dec 4;516(7529):49-50. doi: 10.1038/nature14070. Epub 2014 Nov 19.
Abstract
A new class of fatty acid — found in food and synthesized by mammalian tissues — enhances glucose uptake from the blood and reduces inflammation, suggesting that these fats might be used to treat diabetes.
摘要
一类新型脂肪酸——存在于食物中并由哺乳动物组织合成——可增强从血液中摄取葡萄糖的能力并减轻炎症，这表明这些脂肪可能可用于治疗糖尿病。
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本文引用的文献
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Cell. 2014 Oct 9;159(2):318-32. doi: 10.1016/j.cell.2014.09.035.
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A novel ChREBP isoform in adipose tissue regulates systemic glucose metabolism.脂肪组织中新型 ChREBP 同工型调节全身葡萄糖代谢。
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GPR120 is an omega-3 fatty acid receptor mediating potent anti-inflammatory and insulin-sensitizing effects.GPR120 是一种 omega-3 脂肪酸受体，具有强大的抗炎和胰岛素增敏作用。
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Adipose-selective targeting of the GLUT4 gene impairs insulin action in muscle and liver.对GLUT4基因进行脂肪组织选择性靶向会损害肌肉和肝脏中的胰岛素作用。
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