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[隐匿性应激诱导的动脉高血压]

[Masked stress-induced arterial hypertension].

作者信息

Middeke Martin, Goss F

机构信息

Hypertoniezentrum München, Hypertension Excellence Centre of the European Society of Hypertension (ESH), Herzzentrum Alter Hof München.

出版信息

Dtsch Med Wochenschr. 2014 Nov;139(48):2447-50. doi: 10.1055/s-0034-1387421. Epub 2014 Nov 19.

Abstract

BACKGROUND

Patients who suffer from masked stress-induced arterial hypertension have normal blood pressure values, when measured in the doctor's office, but show elevated values in their everyday life or at work. The two cases, described here, underline the importance of optimal blood pressure measurement and the use of state-of-the-art methods as the basis for recognition and correct classification of this kind of hypertension and for characterization of individual blood pressure profile. This diagnostics is necessary for every therapeutic decision.

HISTORY

Case 1: A now 53-year-old patient first came in six years ago with incidental cardiac dysrhythmia. He stated to suffer from substantial stress at work. Three years previously, an ambulatory blood pressure monitoring (ABPM) showed normal blood pressure levels: daytime mean of 122/78 mmHg (<135/85). Case 2: A 42-year-old patient reported to have had elevated blood pressure for a year and a half, as seen during occasional self-measurements. He, too, suffers from substantial stress at work and, in addition, has a family predisposition for hypertension.

INVESTIGATIONS

Case 1: INVESTIGATIONS showed paroxysmal atrial fibrillation with hypertensive heart disease. Repeated blood pressure measures (brachial and aortal) in the clinic showed normal values when the patient was under standardized exercise testing or at rest. Ambulatory blood pressure monitoring (ABPM) revealed a moderate systolic and a mild diastolic hypertension. Case 2: Both measurements during exercise and at rest showed normal blood pressure values. ABPM showed moderate systolic and severe diastolic hypertension (daytime mean of 150/103 mmHg). Central/aortal blood pressure was also normal (118 mmHg) when measured in the clinic, but severely elevated during ABPM (145 mmHg < 130). There was no hypertension-induced organ damage yet.

TREATMENT

Case 1: Under antihypertensive medication blood pressure has been stabilized at the normal level (ABPM). Atrial fibrillation was permanently removed by catheter ablation. Case 2: According to the patient's wishes, no antihypertensive drug therapy has been initiated yet. The current aim is to normalize the blood pressure by general measures (i.a. stress management).

CONCLUSION

Masked stress-induced arterial hypertension can lead to hypertension-induced organ damage. It has to be revealed via ABPM and therapy must be initiated, despite normal blood pressure levels measured in the clinic. Exact characterization of this kind of hypertension with optimal measuring methods is the prerequisite for individual treatment strategies. This applies particularly to masked hypertension, which is often stress-induced and results in high blood pressure under daily routine.

摘要

背景

患有隐匿性应激性动脉高血压的患者,在医生办公室测量时血压值正常,但在日常生活或工作中血压值会升高。这里描述的两个病例强调了最佳血压测量以及使用先进方法的重要性,这些是识别和正确分类此类高血压以及描绘个体血压特征的基础。这种诊断对于每一个治疗决策都是必要的。

病史

病例1:一名现年53岁的患者六年前首次因偶然发现的心律失常前来就诊。他表示工作压力很大。三年前,动态血压监测(ABPM)显示血压水平正常:日间平均值为122/78 mmHg(<135/85)。病例2:一名42岁的患者报告称,在偶尔的自我测量中发现血压升高已有一年半时间。他在工作中也承受着巨大压力,此外,有高血压家族倾向。

检查

病例1:检查显示阵发性心房颤动合并高血压性心脏病。在诊所对患者进行重复血压测量(肱动脉和主动脉)时,患者在标准化运动测试或休息时血压值正常。动态血压监测(ABPM)显示中度收缩期高血压和轻度舒张期高血压。病例2:运动和休息时的测量血压值均正常。ABPM显示中度收缩期高血压和重度舒张期高血压(日间平均值为150/103 mmHg)。在诊所测量时中心/主动脉血压也正常(118 mmHg),但在ABPM期间严重升高(145 mmHg < 130)。尚未出现高血压引起的器官损害。

治疗

病例1:在抗高血压药物治疗下,血压已稳定在正常水平(ABPM)。通过导管消融术永久性消除了心房颤动。病例2:根据患者意愿,尚未开始抗高血压药物治疗。目前的目标是通过一般措施(包括压力管理)使血压正常化。

结论

隐匿性应激性动脉高血压可导致高血压引起的器官损害。必须通过ABPM揭示这种情况,并且尽管在诊所测量的血压水平正常,也必须开始治疗。用最佳测量方法准确描绘这种高血压是制定个体化治疗策略的前提。这尤其适用于隐匿性高血压,它通常由压力引起,在日常生活中导致高血压。

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