Hellstein John
University of Iowa, Iowa City, IA, USA,
Head Neck Pathol. 2014 Dec;8(4):482-90. doi: 10.1007/s12105-014-0583-z. Epub 2014 Nov 20.
Osteonecrosis of the jaw to a certain extent has been with us for many years. But recently the advent of various medications such as bisphosphonates, VEGF inhibitors, tyrosine kinase inhibitors and humanized antibodies to osteoclastic action have resulted in thousands of cases. While the bisphosphonates continue to be the most common medication associated with osteochemonecrosis antibodies such as denosumab which irreversibly act on osteoclastic action are also being reported. This narrative review will serve as an update with a focus on some of the histopathologic features discussed and reviewed. Perhaps even more uncommonly seen in past reports a discussion of features possibly observed while grossing specimens will be discussed. At the end of this report is hoped that the pathologist will have a better understanding of the historical features, clinical settings, gross examination features as well as histopathologic features associated with osteochemonecrosis.
颌骨骨坏死在一定程度上已经存在多年了。但近年来，双膦酸盐、血管内皮生长因子（VEGF）抑制剂、酪氨酸激酶抑制剂以及针对破骨细胞作用的人源化抗体等各种药物的出现导致了数千例病例。虽然双膦酸盐仍然是与骨化学性坏死相关的最常见药物，但也有报告称，诸如地诺单抗等不可逆作用于破骨细胞作用的抗体。本叙述性综述将作为一次更新，重点关注所讨论和回顾的一些组织病理学特征。在过去的报告中可能更罕见的是，将讨论在大体检查标本时可能观察到的特征。希望通过本报告结尾部分，病理学家能更好地理解与骨化学性坏死相关的历史特征、临床背景、大体检查特征以及组织病理学特征。
