Wang Bo, He Li, Cui Bingzhou, Lv Haixin
Department of Neurosurgery, the People's Hospital of Zhengzhou, Zhengzhou, China.
Department of Endocrinology, Zhengzhou Central Hospital Affiliated to Zhengzhou University, Zhengzhou, China.
Pak J Pharm Sci. 2014 Nov;27(6 Suppl):2035-40.
This paper aimed to verify the function of ginsenoside in the repair of peripheral nerve injury through the model of sciatic nerve injury in rat. The method was to prepare the model of SD rat injury of sciatic nerve, and to conduct treatment with different dose of ginsenoside Rg1. At the same time, the control group was established. The regenerative repair, functional recovery and the situation of target organ, etc. were evaluated by neuromorphic metrology index, fluorescence gold retrograde tag, animal behavior index (sciatic nerve index). The result was the situation of nerve regenerative repair and functional recovery in high dose ginsenoside Rg1 group was obviously superior to other groups, the recovery of sciatic nerve index, target muscle, etc. were fine and mostly close to normal. It was concluded that ginsenoside Rg1 could effectively promote the regenerative repair of peripheral nerve injury, and accelerate the recovery of its nerve function. It could also promote the regeneration of peripheral nerve and the recovery of its nerve function.
本文旨在通过大鼠坐骨神经损伤模型验证人参皂苷在周围神经损伤修复中的作用。方法是制备SD大鼠坐骨神经损伤模型，并用不同剂量的人参皂苷Rg1进行治疗。同时设立对照组。通过神经形态计量指标、荧光金逆行标记、动物行为指标（坐骨神经指数）等评估再生修复、功能恢复及靶器官情况等。结果显示高剂量人参皂苷Rg1组的神经再生修复及功能恢复情况明显优于其他组，坐骨神经指数、靶肌肉等恢复良好且大多接近正常。结论为人参皂苷Rg1可有效促进周围神经损伤的再生修复，加速其神经功能恢复，还可促进周围神经再生及其神经功能恢复。
