NLRP3基因多态性与抵御人类嗜T淋巴细胞病毒1型感染有关。
NLRP3 polymorphism is associated with protection against human T-lymphotropic virus 1 infection.
作者信息
Kamada Anselmo Jiro, Pontillo Alessandra, Guimarães Rafael Lima, Loureiro Paula, Crovella Sergio, Brandão Lucas André Cavalcanti
机构信息
Departamento de Genética, Universidade Federal de Pernambuco, Recife, PE, Brasil.
Laboratório de Imunogenética, Departamento de Imunologia, Instituto de Ciências Biomédicas, Universidade de São Paulo, São Paulo, SP, Brasil.
出版信息
Mem Inst Oswaldo Cruz. 2014 Nov;109(7):960-3.
Inter-individual heterogeneity in the response to human T-lymphotropic virus 1 (HTLV-1) infection has been partially attributed to host genetic background. The antiviral activity of the inflammasome cytoplasmic complex recognises viral molecular patterns and regulates immune responses via the activation of interleukin (IL)-1 family (IL-1, IL-18 and IL-33) members. The association between polymorphisms in the inflammasome receptors NLRP1 and NLRP3 and HTLV-1 infection was evaluated in a northeastern Brazilian population (84 HTLV-1 carriers and 155 healthy controls). NLRP3 rs10754558 G/G was associated with protection against HTLV-1 infection (p = 0.012; odds ratio = 0.37). rs10754558 affects NLRP3 mRNA stability; therefore, our results suggest that higher NLRP3 expression may augment first-line defences, leading to the effective protection against HTLV-1 infection.
个体对人类嗜T淋巴细胞病毒1型（HTLV-1）感染反应的个体间异质性部分归因于宿主遗传背景。炎性小体细胞质复合物的抗病毒活性可识别病毒分子模式，并通过激活白细胞介素（IL）-1家族（IL-1、IL-18和IL-33）成员来调节免疫反应。在巴西东北部人群（84名HTLV-1携带者和155名健康对照）中评估了炎性小体受体NLRP1和NLRP3的多态性与HTLV-1感染之间的关联。NLRP3 rs10754558 G/G与预防HTLV-1感染相关（p = 0.012；优势比 = 0.37）。rs10754558影响NLRP3 mRNA稳定性；因此，我们的结果表明，较高的NLRP3表达可能增强一线防御，从而有效预防HTLV-1感染。
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