Zhang Chunyang, Feng Huasong, Zhang Yan, Lei Xiao, Liang Yingkui, Ding Xinmin, Meng Jiguang, Han Zhihai
raduate Student Team of Medical School of Chinese PLA, Beijing 100853, China. E-mail:
Nan Fang Yi Ke Da Xue Xue Bao. 2014 Nov;34(11):1650-3, 1667.
To explore the value of ¹⁸F-FDG PET-CT in evaluating bronchial mucosa involvement in patients with saroidosis.
A retrospective analysis was conducted among 6 sarcoidosis patients with and 14 patients without bronchial mucosa involvement to collect the data including the standard uptake value (SUVMax/Mean) of ¹⁸F-FDG, serum angiotensin converting enzyme (sACE), and proportion of lymphocytes and CD4⁺/CD8 ⁺ T lymphocyte ratio in bronchoalveolar lavage fluid (BALF).
The lung focal SUV(Max/Mean) was higher in patients with bronchial mucosa involvement than those without (7.04 ± 5.83/5.00 ± 4.69 vs 5.68 ± 3.66/3.82 ± 2.39), but such differences were not statistically significant (P=0.565/0.495). The SUV(Max/Mean) of the hilum of the lung and the mediastina lymph nodes were significantly higher in patients with bronchial mucosa involvement (13.28 ± 5.57/10.48 ± 4.43 vs 6.20 ± 1.77/4.52 ± 1.43, P=0.0003/0.0002; 13.84 ± 4.35/9.69 ± 2.74 vs 7.16 ± 2.52/5.28 ± 1.77, P=0.0004/0.0004). The level of sACE and CD4⁺/CD8 ⁺ T lymphocyte ratio in BALF were also significantly higher in patients with bronchial mucosa involvement (60.58 ± 16.3 vs 49.16 ± 13.3 IU/L, P=0.045; 7.30 ± 5.0 vs 2.90 ± 3.1, P=0.026). The proportion of lymphocytes in BALF was comparable between the patients with and without bronchial mucosa involvement (44.10 ± 10.3% vs 35.30 ± 12.5%, P=0.148).
For patients with saroidosis, ¹⁸F-FDG PET-CT is useful in evaluating bronchial mucosa involvement, which is one of the key features of active sarcoidosis.
探讨¹⁸F-FDG PET-CT在评估结节病患者支气管黏膜受累情况中的价值。
对6例有支气管黏膜受累的结节病患者和14例无支气管黏膜受累的患者进行回顾性分析，收集包括¹⁸F-FDG的标准摄取值（SUVMax/Mean）、血清血管紧张素转换酶（sACE）以及支气管肺泡灌洗液（BALF）中淋巴细胞比例和CD4⁺/CD8⁺T淋巴细胞比值的数据。
支气管黏膜受累患者的肺部局灶性SUV（Max/Mean）高于未受累患者（7.04±5.83/5.00±4.69 vs 5.68±3.66/3.82±2.39），但差异无统计学意义（P=0.565/0.495）。支气管黏膜受累患者的肺门和纵隔淋巴结SUV（Max/Mean）显著更高（13.28±5.57/10.48±4.43 vs 6.20±1.77/4.52±1.43，P=0.0003/0.0002；13.84±4.35/9.69±2.74 vs 7.16±2.52/5.28±1.77，P=0.0004/0.0004）。支气管黏膜受累患者的sACE水平和BALF中CD4⁺/CD8⁺T淋巴细胞比值也显著更高（60.58±16.3 vs 49.16±13.3 IU/L，P=0.045；7.30±5.0 vs 2.90±3.1，P=0.026）。支气管黏膜受累患者与未受累患者BALF中淋巴细胞比例相当（44.10±10.3% vs 35.30±12.5%，P=0.148）。
对于结节病患者而言，¹⁸F-FDG PET-CT有助于评估支气管黏膜受累情况，支气管黏膜受累是活动性结节病的关键特征之一。
