Kawarai Shinpei, Hisasue Masaharu, Matsuura Shinobu, Ito Tetsuro, Inoue Yukari, Neo Sakurako, Fujii Yoko, Madarame Hiroo, Shirota Kinji, Tsuchiya Ryo
From Laboratory of Small Animal Clinics, Veterinary Teaching Hospital (S.K., T.I., H.M.) and Laboratory of Veterinary Internal Medicine II (M.H., Y.I., S.N., R.T.), Laboratory of Veterinary Surgery I (Y.F.), and Laboratory of Veterinary Pathology (K.S.), Department of Veterinary Medicine, Azabu University, Fuchinobe, Chuo-ku, Sagamihara, Kanagawa, Japan; and Center for Advanced Biomedical Research, Boston University School of Medicine, Boston, MA (S.M.).
J Am Anim Hosp Assoc. 2015 Jan-Feb;51(1):56-63. doi: 10.5326/JAAHA-MS-6044. Epub 2014 Nov 21.
A 3 yr old wirehaired fox terrier was presented to his primary care veterinarian with fever, thrombocytopenia, and generalized crusting dermatitis. The skin lesion had progressed for at least 18 days, and thrombocytopenia had developed 3 days before presentation. Histopathology and direct immunofluorescence studies of the skin were consistent with pemphigus foliaceus (PF). Immunofluorescence revealed immunoglobulin G deposition around the keratinocytes in the stratum spinosum. A diagnosis of immune-mediated thrombocytopenia (IMT) was confirmed by the presence of platelet surface-associated immunoglobulin using flow cytometry. Systemic immunosuppressive therapy with cyclosporine and azathioprine was effective, and the dog survived for >2 years from the initial presentation. IMT is rarely associated with PF. This appears to be the first detailed report of a definitive diagnosis of concurrent PF and IMT in a dog. The authors' findings indicate that canine PF could be complicated by hematologic immune-mediated diseases such as IMT.
一只3岁的刚毛猎狐梗被带到其初级保健兽医处，伴有发热、血小板减少和全身性结痂性皮炎。皮肤病变至少已发展了18天，血小板减少在就诊前3天出现。皮肤的组织病理学和直接免疫荧光研究与落叶型天疱疮（PF）一致。免疫荧光显示棘层角质形成细胞周围有免疫球蛋白G沉积。通过流式细胞术检测到血小板表面相关免疫球蛋白，从而确诊为免疫介导性血小板减少症（IMT）。使用环孢素和硫唑嘌呤进行的全身免疫抑制治疗有效，这只狗自初次就诊后存活了2年多。IMT很少与PF相关。这似乎是第一份关于犬同时患有PF和IMT的确切诊断的详细报告。作者的研究结果表明，犬PF可能并发血液学免疫介导性疾病，如IMT。
