Reinhardt H
Neurochirurgische Universitätsklinik, Departement Chirurgie, Kantonsspital, Basel, Switzerland.
Acta Neurochir (Wien). 1989;97(3-4):89-94. doi: 10.1007/BF01772816.
In a series of 60 patients 62 intraoperative measurements with the 32-P (radiophosphorus) tumour marker were performed. Using miniature semiconductor probes a reliable discrimination between normal brain and neoplastic tissue was possible in nearly all brain tumours. The best results were found in meningiomas, where even small, visually hardly discernible tumour resides within the matrix zone could be reliably detected. Only in low-grade gliomas the application of the 32-P marker was impossible due to count rates similar to or below the basic rates of normal brain. This simple to use, non-invasive method proved its usefulness in all situations where a local radical tumour removal was important.
对60例患者进行了62次术中使用32-P（放射性磷）肿瘤标志物的测量。使用微型半导体探头，几乎在所有脑肿瘤中都能可靠地区分正常脑组织和肿瘤组织。在脑膜瘤中取得了最佳结果，即使是基质区内肉眼几乎难以察觉的小肿瘤也能被可靠检测到。仅在低级别胶质瘤中，由于计数率与正常脑的基本率相似或低于正常脑的基本率，无法应用32-P标志物。这种简单易用、非侵入性的方法在所有局部根治性切除肿瘤很重要的情况下都证明了其有效性。
