Moscinski L C, So A L, Russell J E, Kant J A, Prystowsky M B
Department of Pathology, Hospital of the University of Pennsylvania, Philadelphia.
Am J Clin Pathol. 1989 May;91(5):607-12. doi: 10.1093/ajcp/91.5.607.
Acute megakaryoblastic leukemia (FABM7) is an unusual but well recognized form of acute myelogenous leukemia in which the bone marrow blast cells are phenotypically recognized by the demonstration of cytoplasmic platelet peroxidase or surface staining for the IIb/IIIa platelet-specific glycoprotein. Herein, the authors report a case of acute megakaryoblastic leukemia that satisfies the accepted French-American-British criteria and in which the blast cells also exhibit evidence of myeloid differentiation, including surface MY7 (CD13) by flow cytometry and immunocytochemical positivity for myeloperoxidase. These findings suggest that megakaryoblasts may be closely related to myelomonoblasts, that they have the potential to partially differentiate along multiple phenotypic lines, and that aberrant phenotypes can occur that do not correspond to known stages of normal maturation. The authors illustrate the difficulty in classification of these aberrant phenotypes by standard cytochemical and morphologic criteria.
急性巨核细胞白血病（FABM7）是一种不常见但已得到充分认识的急性髓细胞白血病形式，其中骨髓原始细胞通过细胞质血小板过氧化物酶的显示或IIb/IIIa血小板特异性糖蛋白的表面染色在表型上得以识别。在此，作者报告了一例符合公认的法美英标准的急性巨核细胞白血病病例，其中原始细胞还表现出髓系分化的证据，包括通过流式细胞术检测到表面MY7（CD13）以及髓过氧化物酶免疫细胞化学呈阳性。这些发现表明，巨核母细胞可能与粒单核母细胞密切相关，它们有可能沿多种表型路线进行部分分化，并且可能出现与正常成熟已知阶段不相符的异常表型。作者阐述了通过标准细胞化学和形态学标准对这些异常表型进行分类的困难。
