D-手性肌醇治疗后多囊卵巢综合征女性的卵巢功能和代谢因素评估

Evaluation of ovarian function and metabolic factors in women affected by polycystic ovary syndrome after treatment with D-Chiro-Inositol.

作者信息

Laganà Antonio Simone, Barbaro Luisa, Pizzo Alfonsa

机构信息

Department of Pediatric Gynecological, Microbiological and Biomedical Sciences, University of Messina, Via C. Valeria 1, 98125, Messina, Italy,

出版信息

Arch Gynecol Obstet. 2015 May;291(5):1181-6. doi: 10.1007/s00404-014-3552-6. Epub 2014 Nov 22.

DOI:10.1007/s00404-014-3552-6

PMID:25416201

Abstract

PURPOSE

To evaluate the effects of D-Chiro-Inositol in women affected by polycystic ovary syndrome (PCOS).

METHODS

We enrolled 48 patients, with homogeneous bio-physical characteristics, affected by PCOS and menstrual irregularities. These patients underwent treatment with 1 gr of D-Chiro-Inositol/die plus 400 mcg of Folic Acid/die orally for 6 months. We analyzed pre-treatment and post-treatment BMI, Systolic and Diastolic blood pressure, Ferriman-Gallwey score, Cremoncini score, serum LH, LH/FSH ratio, total and free testosterone, DHEA-S, Δ-4-androstenedione, SHBG, prolactin, glucose/IRI ratio, HOMA index, and resumption of regular menstrual cycles.

RESULTS

We evidenced a statistically significant reduction of systolic blood pressure, Ferriman-Gallwey score, LH, LH/FSH ratio, total Testosterone, free Testosterone, ∆-4-Androstenedione, Prolactin, and HOMA Index; in the same patients, we noticed a statistically significant increase of SHBG and Glycemia/IRI ratio. Moreover, we observed statistically significant (62.5%; p < 0.05) post-treatment menstrual cycle regularization.

CONCLUSIONS

D-Chiro-Inositol is effective in improving ovarian function and metabolism of patients affected by PCOS.

摘要

目的

评估D-手性肌醇对多囊卵巢综合征（PCOS）女性的影响。

方法

我们招募了48例具有相似生物物理特征、患有PCOS且月经不规律的患者。这些患者接受每日1克D-手性肌醇加每日400微克叶酸的口服治疗，为期6个月。我们分析了治疗前和治疗后的体重指数（BMI）、收缩压和舒张压、费里曼-盖尔维评分、克雷蒙奇尼评分、血清促黄体生成素（LH）、LH/FSH比值、总睾酮和游离睾酮、硫酸脱氢表雄酮（DHEA-S）、Δ-4-雄烯二酮、性激素结合球蛋白（SHBG）、催乳素、血糖/胰岛素抵抗指数（IRI）比值、稳态模型评估胰岛素抵抗指数（HOMA指数）以及月经周期恢复正常的情况。