Laganà Antonio Simone, Barbaro Luisa, Pizzo Alfonsa
Department of Pediatric Gynecological, Microbiological and Biomedical Sciences, University of Messina, Via C. Valeria 1, 98125, Messina, Italy,
Arch Gynecol Obstet. 2015 May;291(5):1181-6. doi: 10.1007/s00404-014-3552-6. Epub 2014 Nov 22.
To evaluate the effects of D-Chiro-Inositol in women affected by polycystic ovary syndrome (PCOS).
We enrolled 48 patients, with homogeneous bio-physical characteristics, affected by PCOS and menstrual irregularities. These patients underwent treatment with 1 gr of D-Chiro-Inositol/die plus 400 mcg of Folic Acid/die orally for 6 months. We analyzed pre-treatment and post-treatment BMI, Systolic and Diastolic blood pressure, Ferriman-Gallwey score, Cremoncini score, serum LH, LH/FSH ratio, total and free testosterone, DHEA-S, Δ-4-androstenedione, SHBG, prolactin, glucose/IRI ratio, HOMA index, and resumption of regular menstrual cycles.
We evidenced a statistically significant reduction of systolic blood pressure, Ferriman-Gallwey score, LH, LH/FSH ratio, total Testosterone, free Testosterone, ∆-4-Androstenedione, Prolactin, and HOMA Index; in the same patients, we noticed a statistically significant increase of SHBG and Glycemia/IRI ratio. Moreover, we observed statistically significant (62.5%; p < 0.05) post-treatment menstrual cycle regularization.
D-Chiro-Inositol is effective in improving ovarian function and metabolism of patients affected by PCOS.
评估D-手性肌醇对多囊卵巢综合征（PCOS）女性的影响。
我们招募了48例具有相似生物物理特征、患有PCOS且月经不规律的患者。这些患者接受每日1克D-手性肌醇加每日400微克叶酸的口服治疗，为期6个月。我们分析了治疗前和治疗后的体重指数（BMI）、收缩压和舒张压、费里曼-盖尔维评分、克雷蒙奇尼评分、血清促黄体生成素（LH）、LH/FSH比值、总睾酮和游离睾酮、硫酸脱氢表雄酮（DHEA-S）、Δ-4-雄烯二酮、性激素结合球蛋白（SHBG）、催乳素、血糖/胰岛素抵抗指数（IRI）比值、稳态模型评估胰岛素抵抗指数（HOMA指数）以及月经周期恢复正常的情况。
我们发现收缩压、费里曼-盖尔维评分、LH、LH/FSH比值、总睾酮、游离睾酮、Δ-4-雄烯二酮、催乳素和HOMA指数有统计学意义的显著降低；在同一批患者中，我们注意到SHBG和血糖/IRI比值有统计学意义的显著升高。此外，我们观察到治疗后月经周期恢复正常具有统计学意义（62.5%；p<0.05）。
D-手性肌醇对改善PCOS患者的卵巢功能和代谢有效。
