Sun Chunlong, Cai Jin, Chen Junqing, Wu Yang, Wang Peng, Zhou Gaoxin, Zong Xi, Chen Bo, Lv Yongfeng, Ji Min
School of Chemistry and Chemical Engineering, Southeast University, Nanjing, 210096, China,
Appl Biochem Biotechnol. 2015 Feb;175(3):1644-50. doi: 10.1007/s12010-014-1398-9. Epub 2014 Nov 22.
IR-780, a novel near-infrared (NIR) fluorescent probe, was synthesized and applied to living cells. The probe exhibited good fluorescent characteristic, and cell experiments showed the probe had high affinity and without apparent cytotoxicity. Fluorescent image experiments in living A549 (Human lung adenocarcinoma epithelial cell line) and L929 (mouse fibroblast cell line) cells, further demonstrated its potential applications in biological systems. The probe effectively prevented the influence of autofluorescence and native cellular species in biological systems. It also exhibited excellent cell membrane permeability, good photostability, and high sensitivity.
新型近红外（NIR）荧光探针IR-780被合成并应用于活细胞。该探针表现出良好的荧光特性，细胞实验表明该探针具有高亲和力且无明显细胞毒性。在活的A549（人肺腺癌上皮细胞系）和L929（小鼠成纤维细胞系）细胞中进行的荧光成像实验，进一步证明了其在生物系统中的潜在应用。该探针有效防止了生物系统中自发荧光和天然细胞成分的影响。它还表现出优异的细胞膜通透性、良好的光稳定性和高灵敏度。
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