Mumm Hanne, Jensen Dorte Møller, Sørensen Jens Aage, Andersen Lise Lotte Torvin, Ravn Pernille, Andersen Marianne, Glintborg Dorte
Department of Endocrinology and Metabolism, Odense University Hospital, Odense, Denmark.
Acta Obstet Gynecol Scand. 2015 Feb;94(2):204-11. doi: 10.1111/aogs.12545. Epub 2014 Dec 25.
To investigate obstetric outcomes in Danish women with different phenotypes of polycystic ovary syndrome (PCOS) and isolated hyperandrogenism (HA) and describe the risk of adverse obstetric outcomes in women with PCOS and HA compared to controls.
Cohort study.
Odense University Hospital, Denmark.
Women with PCOS were identified prospectively starting in 1997. Singleton pregnancies in women with PCOS and HA during 2003-2011 were included (n = 199). A control group was matched to the patient cohort according to date of childbirth (n = 995).
Data on clinical characteristics and obstetric outcomes were collected in patients with PCOS and HA and controls. In PCOS and HA, total and free testosterone, sex hormone binding globulin, and hemoglobin A1c were measured outside pregnancy. During pregnancy, oral glucose tolerance tests were performed in 39 patients and 123 controls according to Danish national guidelines. PCOS phenotypes were based on the Rotterdam criteria.
Gestational diabetes mellitus, pregnancy-induced hypertension, preeclampsia, delivery by emergency cesarean section, preterm delivery and anthropometric measures in the newborn.
The incidence of adverse obstetric outcomes and anthropometric measures among the newborns were comparable between different phenotypes of PCOS and patients with HA. In the oral glucose tolerance test, patients had a higher risk of gestational diabetes mellitus compared with controls; the odds ratio (95% confidence interval) was 3.3 (1.5-6.9) after adjustment for age, parity, and body mass index (p = 0.002). The incidence of other adverse obstetric outcomes was similar in patients and controls.
Obstetric outcomes were comparable in women with different PCOS phenotypes.
研究丹麦患有不同表型多囊卵巢综合征（PCOS）和单纯高雄激素血症（HA）的女性的产科结局，并描述与对照组相比，PCOS和HA女性发生不良产科结局的风险。
队列研究。
丹麦欧登塞大学医院。
自1997年起前瞻性地识别出患有PCOS的女性。纳入2003年至2011年期间患有PCOS和HA的单胎妊娠女性（n = 199）。根据分娩日期将对照组与患者队列进行匹配（n = 995）。
收集PCOS和HA患者及对照组的临床特征和产科结局数据。在PCOS和HA患者中，在非孕期测量总睾酮、游离睾酮、性激素结合球蛋白和糖化血红蛋白A1c。在孕期，根据丹麦国家指南，对39例患者和123例对照进行口服葡萄糖耐量试验。PCOS表型基于鹿特丹标准。
妊娠期糖尿病、妊娠高血压、子痫前期、急诊剖宫产分娩、早产以及新生儿人体测量指标。
不同表型的PCOS患者和HA患者中，不良产科结局的发生率以及新生儿人体测量指标具有可比性。在口服葡萄糖耐量试验中，与对照组相比，患者患妊娠期糖尿病的风险更高；在调整年龄、产次和体重指数后，比值比（95%置信区间）为3.3（1.5 - 6.9）（p = 0.002）。患者和对照组中其他不良产科结局的发生率相似。
不同PCOS表型的女性产科结局具有可比性。
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