Kavardzhikova S, Pechlivanov B
Akush Ginekol (Sofiia). 2010;49(4):32-7.
Our aim was to investigate the percentage occurrence of different phenotypes of polycystic ovary syndrome (PCOS) in a Bulgarian population, and their clinical, metabolic and hormonal characteristics.
The study included 110 women with PCOS, diagnosed according to the Europian Society of Human Reproduction & Embriology/American Society for Reproductive Medicine criteria. The women were divided into four phenotypes: hyperandrogenism (HA) + oligo-/ anovulation (OA) + polycystic ovaries at ultrasound (PCO) ( full-blown syndrome, phenotype A); HA + OA (former Institute of Health definition, phenotype B); OA + PCO (phenotype C); and HA + PCO (phenotype D). Serum levels of testosteron, immune-reactive insulin, sex hormone-binding globulin, dehydroepiandrosterone sulfate and lipid metabolism parameters were measured. Free androgen index and homeostasis model assessment of insulin resistance were calculated. Body mass index and waist- to--hip ratio were assessed.
The percentage of phenotypes A, B, C and D in a Bulgarian Population are 53.6%, 12.8%, 11%, 22.6% respectively. The women with the classical form of PCOS (phenotypes A and B) were more obese, had more strongly expressed hyperandrogenemia, and were more insulin--resistant compared with the women of phenotypes C and D.
There is a significant difference in anthropometric, hormonal and metabolic indices between the classical form and the clinical variants of PCOS in the studied Bulgarian population.
我们的目的是调查保加利亚人群中多囊卵巢综合征（PCOS）不同表型的发生率及其临床、代谢和激素特征。
该研究纳入了110名根据欧洲人类生殖与胚胎学会/美国生殖医学学会标准诊断为PCOS的女性。这些女性被分为四种表型：高雄激素血症（HA）+少/无排卵（OA）+超声检查显示多囊卵巢（PCO）（典型综合征，表型A）；HA+OA（原健康研究所定义，表型B）；OA+PCO（表型C）；以及HA+PCO（表型D）。测量了血清睾酮、免疫反应性胰岛素、性激素结合球蛋白、硫酸脱氢表雄酮和脂质代谢参数。计算了游离雄激素指数和胰岛素抵抗的稳态模型评估值。评估了体重指数和腰臀比。
保加利亚人群中表型A、B、C和D的百分比分别为53.6%、12.8%、11%、22.6%。与表型C和D的女性相比，具有典型PCOS形式（表型A和B）的女性更肥胖，高雄激素血症表达更强，胰岛素抵抗更明显。
在所研究的保加利亚人群中，PCOS的典型形式与临床变异型在人体测量、激素和代谢指标方面存在显著差异。
