Laredo Reyna María Nataly, Falen Bogio Juan Manuel, Lipa Chancolla Roxana, Núñez Almache Oswaldo, Pinto Paola, Espinoza Robles Oscar, Chávez Eliana, Rojas Gabulli María Isabel, Del Aguila Villar Carlos
Instituto Nacional de Salud del Niño, Lima, Perú
Facultad de Medicina, Universidad Nacional Federico Villareal, Lima, Perú
Rev Peru Med Exp Salud Publica. 2014 Jul-Sep;31(3):588-94.
A case is reported of a 7 year old patient with progressive dyspnea and genital development according to Marshall and Tanner criteria at the G2 VP3 stage. A mass of regular and well-defined borders was found in the chest, with calcifications and cystic areas of heterogeneous content. Basal measurements of FSH, LH and testosterone were <10 mIU/mL, 12.2 mIU/mL and 724 ng/dL, respectively. α-fetoprotein was 145.1 ng/mL. Excising the tumor improved respiratory symptoms, diminished hormone levels and stopped the process of precocious puberty. Pathology of the mediastinal tumor corresponded to a germ cell tumor with a predominant component of mature teratoma and choriocarcinoma. Neoplastic causes of precocious puberty are uncommon; its diagnosis is essential in order to provide timely treatment.
报告了一例7岁患者,有进行性呼吸困难,且根据马歇尔和坦纳标准处于G2 VP3期生殖器发育状态。胸部发现一个边界规则且清晰的肿块,伴有钙化和内容物不均一的囊性区域。促卵泡生成素(FSH)、促黄体生成素(LH)和睾酮的基础测量值分别<10 mIU/mL、12.2 mIU/mL和724 ng/dL。甲胎蛋白为145.1 ng/mL。切除肿瘤改善了呼吸症状,降低了激素水平,并停止了性早熟进程。纵隔肿瘤的病理结果为生殖细胞肿瘤,主要成分是成熟畸胎瘤和绒毛膜癌。性早熟的肿瘤性病因并不常见;其诊断对于及时治疗至关重要。