蛋白质-DNA相互作用与染色体组织的生物物理学
Biophysics of protein-DNA interactions and chromosome organization.
作者信息
Marko John F
机构信息
Department of Physics & Astronomy and Department of Molecular Biosciences, Northwestern University, Evanston, Illinois USA 60208.
出版信息
Physica A. 2015 Jan 15;418:126-153. doi: 10.1016/j.physa.2014.07.045.
Abstract
The function of DNA in cells depends on its interactions with protein molecules, which recognize and act on base sequence patterns along the double helix. These notes aim to introduce basic polymer physics of DNA molecules, biophysics of protein-DNA interactions and their study in single-DNA experiments, and some aspects of large-scale chromosome structure. Mechanisms for control of chromosome topology will also be discussed.
摘要
DNA在细胞中的功能取决于它与蛋白质分子的相互作用，这些蛋白质分子能够识别双螺旋上的碱基序列模式并对其产生作用。本笔记旨在介绍DNA分子的基础聚合物物理学、蛋白质-DNA相互作用的生物物理学及其在单DNA实验中的研究，以及大规模染色体结构的一些方面。还将讨论控制染色体拓扑结构的机制。
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