铪和钛涂层植入物对兔骨合成后几种血液生化标志物的影响。
Effect of hafnium and titanium coated implants on several blood biochemical markers after osteosynthesis in rabbits.
作者信息
Yousef Ashraf, Akhtyamov Ildar, Shakirova Faina, Zubairova Lyaili, Gatina Elmira, Aliev Capital Ie Cyrilliclchin
机构信息
Department of Orthopedic Surgery, New Mowasat Hospital Salmiya, Kuwait.
Department of Traumatology, Orthopedics and Extreme Medicine, Kazan State Medical University Kazan, Russia ; Republic Clinical Hospital Kazan, Russia.
出版信息
Int J Clin Exp Med. 2014 Oct 15;7(10):3473-7. eCollection 2014.
PURPOSE
An experimental study comparing the dynamics of several biochemical markers before and after osteosynthesis, utilizing implants coated with titanium and hafnium nitrides and non-coated implants on rabbits' bones.
MATERIALS AND METHODS
The Study has been conducted on 30 rabbits of both sexes, at the age of 6-7 months, weighing 2526.5±74.4 gm. Animals underwent open osteotomy of the tibia in the middle third of the diaphysis followed by the intramedullary nailing. The level of alkaline phosphatase, calcium, phosphorus, total protein, glucose, ALT and AST were monitored for 60 days.
RESULTS
the use of implants coated with titanium and hafnium nitrides, which have high strength, thermal and chemical stability, was not accompanied by the development of additional negative reactive changes compared to non-coated implants.
CONCLUSION
Nanotechnology used in manufacturing bioinert coatings for implants for osteosynthesis, has made the post-operative period less complicated as reflected by less expressed changing in the markers of bone metabolism and hepatotoxicity.
目的
一项实验研究，比较在兔骨上使用涂有氮化钛和氮化铪的植入物及未涂层植入物进行骨合成前后几种生化标志物的动态变化。
材料与方法
对30只6 - 7个月大、体重2526.5±74.4克的雌雄兔进行了研究。动物在骨干中三分之一处进行胫骨开放性截骨术，随后进行髓内钉固定。监测碱性磷酸酶、钙、磷、总蛋白、葡萄糖、谷丙转氨酶和谷草转氨酶水平60天。
结果
与未涂层植入物相比，使用具有高强度、热稳定性和化学稳定性的涂有氮化钛和氮化铪的植入物，并未伴随额外的负面反应性变化。
结论
用于制造骨合成植入物生物惰性涂层的纳米技术，使术后时期并发症减少，这体现在骨代谢和肝毒性标志物变化较小。
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