内皮功能障碍与冠状动脉疾病：一篇最新综述

Endothelial dysfunction and coronary artery disease: a state of the art review.

作者信息

Veerasamy Murugapathy, Bagnall Alan, Neely Dermot, Allen John, Sinclair Hannah, Kunadian Vijay

机构信息

From the *Institute of Cellular Medicine, Faculty of Medical Sciences, Newcastle University, United Kingdom; †Cardiothoracic Centre, Freeman Hospital, Newcastle-upon-Tyne Hospitals NHS Foundation Trust, Newcastle-upon-Tyne, United Kingdom; ‡Department of Biochemistry, Newcastle-upon-Tyne Hospitals NHS Foundation Trust, Newcastle-upon-Tyne, United Kingdom; and §Regional Medical Physics Department, Freeman Hospital, Newcastle-upon-Tyne Hospitals NHS Foundation Trust, Newcastle-upon-Tyne, United Kingdom.

出版信息

Cardiol Rev. 2015 May-Jun;23(3):119-29. doi: 10.1097/CRD.0000000000000047.

DOI:10.1097/CRD.0000000000000047

PMID:25420051

Abstract

Atherosclerotic coronary artery disease (CAD) is a major cause of morbidity and mortality in the developed world. Endothelial dysfunction plays an important role in the development of atherosclerosis and predicts cardiovascular (CV) outcomes independent of conventional CV risk factors. In recent years, there have been tremendous improvements in the pharmacological prevention and management of CAD. In this review, the pathophysiology of endothelial dysfunction in relation to CAD is discussed and various techniques of invasive and noninvasive assessments of peripheral and coronary endothelial function described. In addition, evidence for the association of endothelial dysfunction and CV outcomes has been examined and finally the role of therapeutic interventions in endothelial dysfunction has been discussed.

摘要

动脉粥样硬化性冠状动脉疾病（CAD）是发达国家发病和死亡的主要原因。内皮功能障碍在动脉粥样硬化的发展中起重要作用，并独立于传统心血管危险因素预测心血管（CV）结局。近年来，CAD的药物预防和管理有了巨大进展。在本综述中，讨论了与CAD相关的内皮功能障碍的病理生理学，并描述了外周和冠状动脉内皮功能的侵入性和非侵入性评估的各种技术。此外，还研究了内皮功能障碍与CV结局关联的证据，最后讨论了治疗干预在内皮功能障碍中的作用。