Champa Devora, Di Cristofano Antonio
Department of Developmental and Molecular Biology, Albert Einstein College of Medicine, 1301 Morris Park Avenue, Room 302, Bronx, NY, 10461, USA.
Horm Cancer. 2015 Feb;6(1):37-44. doi: 10.1007/s12672-014-0208-8. Epub 2014 Nov 25.
Anaplastic thyroid carcinoma is the least common form of thyroid cancer; however, it accounts for the majority of deaths associated with this family of malignancies. A number of genetically engineered immunocompetent mouse models recapitulating the genetic and histological features of anaplastic thyroid cancer have been very recently generated and represent an invaluable tool to dissect the mechanisms involved in the progression from indolent, well-differentiated tumors to aggressive, undifferentiated carcinomas and to identify novel therapeutic targets. In this review, we focus on the relevant characteristics associated with these models and on what we have learned in terms of anaplastic thyroid cancer biology, genetics, and response to targeted therapy.
间变性甲状腺癌是甲状腺癌最不常见的形式；然而，它占与这类恶性肿瘤相关死亡人数的大多数。最近已经构建了一些能够重现间变性甲状腺癌的遗传和组织学特征的基因工程免疫活性小鼠模型，这些模型是剖析惰性、高分化肿瘤向侵袭性、未分化癌进展所涉及机制以及鉴定新治疗靶点的宝贵工具。在本综述中，我们重点关注与这些模型相关的特征，以及我们在间变性甲状腺癌生物学、遗传学和靶向治疗反应方面所学到的知识。
