钯催化咪唑酮与芳基卤化物和烯基卤化物的直接C-H官能化反应。
Pd-Catalyzed direct C-H functionalization of imidazolones with aryl- and alkenyl halides.
作者信息
Muselli Mickaël, Baudequin Christine, Hoarau Christophe, Bischoff Laurent
机构信息
Mickaël Muselli, Christine Baudequin, Christophe Hoarau, Laurent Bischoff Normandie Univ, COBRA, UMR 6014 et FR 3038, Univ Rouen, INSA Rouen, CNRS, IRCOF, 1 rue Tesnière, 76821 Mont Saint Aignan Cedex, France.
出版信息
Chem Commun (Camb). 2015 Jan 14;51(4):745-8. doi: 10.1039/c4cc07917e.
PMID:25420541
Abstract
Direct C-H arylation and alkenylation of 4,4'-dialkylimidazolones with a broad range of halides under palladium and copper catalysis have been developed. This methodology is applied to the preparation of recently discovered fatty acid synthetase (FAS) inhibitors.
摘要
已开发出在钯和铜催化下4,4'-二烷基咪唑啉酮与多种卤化物的直接C-H芳基化和烯基化反应。该方法用于制备最近发现的脂肪酸合成酶（FAS）抑制剂。
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