Avoseh Opeyemi N, Oyedeji Ope-oluwa O, Aremu Kayode, Nkeh-Chungag Benedicta N, Songca Sandile P, Oluwafemi Samuel O, Oyedeji Adebola O
a Department of Chemistry , Faculty of Science and Agriculture, University of Fort Hare , Alice , South Africa.
Nat Prod Res. 2015;29(12):1184-8. doi: 10.1080/14786419.2014.983504. Epub 2014 Nov 25.
The volatile oils of the leaves and the stem bark of Acacia mearnsii de Wild obtained by hydro-distillation were analysed by gas chromatography-mass spectrometry. A total of 20, 38, 29 and 38 components accounted for 93.8%, 92.1%, 78.5% and 90.9% of the total oils of the fresh, dry leaves and fresh, dry stem bark, respectively. The major components of the oil were octadecyl alcohol (25.5%) and phytol (10.5%); cis-verbenol (29.5%); phytol (10.1%) and phytol (23.4%) for the fresh leaves, dried leaves, fresh stem, dry stem bark, respectively. Oral administration of essential oils at a dose of 2% showed significant (p < 0.05) anti-inflammatory properties in the albumin-induced test model in rats. Oils from the fresh leaves and dry stems inhibited inflammation beyond 4 h post treatment. The potent anti-inflammatory activity of essential oils of A. mearnsii hereby confirmed its traditional use in treating various inflammatory diseases.
采用气相色谱-质谱联用技术对黑荆树（Acacia mearnsii de Wild）叶和茎皮经水蒸馏得到的挥发油进行了分析。新鲜叶、干叶、新鲜茎皮和干茎皮挥发油中分别有20种、38种、29种和38种成分，分别占挥发油总量的93.8%、92.1%、78.5%和90.9%。该挥发油的主要成分分别为十八醇（25.5%）和叶绿醇（10.5%）；顺式马鞭草烯醇（29.5%）；新鲜叶、干叶、新鲜茎、干茎皮中的叶绿醇含量分别为10.1%和23.4%。在大鼠白蛋白诱导的试验模型中，以2%的剂量口服精油具有显著的抗炎特性（p < 0.05）。新鲜叶和干茎中的精油在治疗后4小时以上仍能抑制炎症。黑荆树精油的强效抗炎活性在此证实了其在治疗各种炎症性疾病方面的传统用途。
