Chen Chin-I, Hsu Ming-I, Lin Shyh-Hsiang, Chang Yuan-Chin I, Hsu Chun-Sen, Tzeng Chii-Ruey
Department of Neurology and.
Gynecol Endocrinol. 2015 Apr;31(4):264-8. doi: 10.3109/09513590.2014.984676. Epub 2014 Nov 25.
The objective of this study was to evaluate the adiponectin and leptin levels in overweight/obese and lean women with polycystic ovary syndrome (PCOS).
This was a retrospective study.
Of the 422 studied patients, 224 women with PCOS and 198 women without PCOS were evaluated.
MAIN OUTCOME MEASURE(S): Insulin resistance and the metabolic components were assessed. The adiponectin and leptin levels were also evaluated.
Adiponectin was negatively correlated with insulin resistance, body mass index (BMI), and total testosterone, triglyceride, and low-density lipoprotein (LDL) levels; conversely, leptin reversed the aforementioned reaction and was negatively correlated with adiponectin levels. The adiponectin to leptin ratios were significantly lower in PCOS women than in those without PCOS. Compared to women with non-PCOS, overweight/obese women with PCOS had lower serum adiponectin levels than women without PCOS, which was not the case for lean women. Conversely, lean women with PCOS had higher serum leptin levels than those without PCOS, which was not the case for overweight/obese women.
Adipose tissue might play an important role in the metabolic complications in women with PCOS. To study the impact of obesity biomarkers in women with PCOS, overweight/obese and lean women should be considered separately.
本研究的目的是评估超重/肥胖和体型偏瘦的多囊卵巢综合征（PCOS）女性体内脂联素和瘦素水平。
这是一项回顾性研究。
在422名接受研究的患者中，对224名PCOS女性和198名非PCOS女性进行了评估。
评估胰岛素抵抗和代谢成分。还评估了脂联素和瘦素水平。
脂联素与胰岛素抵抗、体重指数（BMI）、总睾酮、甘油三酯和低密度脂蛋白（LDL）水平呈负相关；相反，瘦素则呈现相反反应，且与脂联素水平呈负相关。PCOS女性的脂联素与瘦素比值显著低于非PCOS女性。与非PCOS女性相比，超重/肥胖的PCOS女性血清脂联素水平低于非PCOS女性，体型偏瘦的PCOS女性则不然。相反，体型偏瘦的PCOS女性血清瘦素水平高于非PCOS女性，超重/肥胖的PCOS女性则不然。
脂肪组织可能在PCOS女性的代谢并发症中起重要作用。为研究肥胖生物标志物对PCOS女性的影响，应分别考虑超重/肥胖和体型偏瘦的女性。
