Schüler-Toprak Susanne, Ortmann Olaf, Buechler Christa, Treeck Oliver
Department of Gynecology and Obstetrics, University Medical Center Regensburg, 93053 Regensburg, Germany.
Department of Internal Medicine I, University Medical Center Regensburg, 93053 Regensburg, Germany.
Biomedicines. 2022 Oct 7;10(10):2503. doi: 10.3390/biomedicines10102503.
Polycystic ovary syndrome (PCOS) and endometriosis are frequent diseases of the female reproductive tract causing high morbidity as they can significantly affect fertility and quality of life. Adipokines are pleiotropic signaling molecules secreted by white or brown adipose tissues with a central role in energy metabolism. More recently, their involvement in PCOS and endometriosis has been demonstrated. In this review article, we provide an update on the role of adipokines in both diseases and summarize previous findings. We also address the results of multi-omics approaches in adipokine research to examine the role of single nucleotide polymorphisms (SNPs) in genes coding for adipokines and their receptors, the secretome of adipocytes and to identify epigenetic alterations of adipokine genes that might be conferred from mother to child. Finally, we address novel data on the role of brown adipose tissue (BAT), which seems to have notable effects on PCOS. For this review, original research articles on adipokine actions in PCOS and endometriosis are considered, which are listed in the PubMed database.
多囊卵巢综合征（PCOS）和子宫内膜异位症是女性生殖道常见疾病，发病率较高，因为它们会显著影响生育能力和生活质量。脂肪因子是白色或棕色脂肪组织分泌的多效性信号分子，在能量代谢中起核心作用。最近，已证实它们与PCOS和子宫内膜异位症有关。在这篇综述文章中，我们提供了脂肪因子在这两种疾病中作用的最新信息，并总结了先前的研究结果。我们还讨论了脂肪因子研究中多组学方法的结果，以研究编码脂肪因子及其受体的基因中的单核苷酸多态性（SNP）的作用、脂肪细胞的分泌组，并确定可能从母亲传给孩子的脂肪因子基因的表观遗传改变。最后，我们讨论了关于棕色脂肪组织（BAT）作用的新数据，棕色脂肪组织似乎对PCOS有显著影响。在撰写本综述时，我们参考了PubMed数据库中列出的关于脂肪因子在PCOS和子宫内膜异位症中作用的原始研究文章。
