Mardanova A M, Bogomol'naia L M, Romanova Iu D, Sharipova M R
Mikrobiologiia. 2014 Jan-Feb;83(1):3-14.
A widespread bacterium Serratia marcescens (family Enterobacteriaceae) is an opportunistic and exhibits multiple drug resistance. Active removal of antibiotics and other antimicrobials from pathogen and exhibits multiple drug resistance. Active removal of antibiotics and other antimicrobials from the cells by efflux systems is one of the mechanisms responsible for microbial resistance to these compounds. Among enterobacteria, efflux systems of Escherichia coli and Salmonella enterica var. Typhimurium have been studied most extensively. Few efflux systems that belong to different families have been reported for S. marcescens. In this review, we analyzed available literature about S. marcescens efflux systems and carried out the comparative analysis of the genes encoding the RND type systems in different Serratia species and in other enterobacteria. Bioinformatical analysis of the S. marcescens genome allowed us to identify the previously unknown efflux systems based on their homology with the relevant E. coli genes. Identification of additional efflux systems in S. marcescens genome will promote our understanding of physiology of these bacteria, will detect new molecular mechanisms of resistance and will reveal their resistance potential.
广泛存在的粘质沙雷氏菌（肠杆菌科）是一种机会致病菌，具有多重耐药性。从病原体中主动清除抗生素和其他抗菌剂并表现出多重耐药性。通过外排系统从细胞中主动清除抗生素和其他抗菌剂是微生物对这些化合物产生耐药性的机制之一。在肠杆菌中，大肠杆菌和鼠伤寒沙门氏菌的外排系统研究最为广泛。关于粘质沙雷氏菌，很少有属于不同家族的外排系统被报道。在本综述中，我们分析了关于粘质沙雷氏菌外排系统的现有文献，并对不同沙雷氏菌属物种和其他肠杆菌中编码RND型系统的基因进行了比较分析。对粘质沙雷氏菌基因组的生物信息学分析使我们能够基于其与相关大肠杆菌基因的同源性鉴定出先前未知的外排系统。在粘质沙雷氏菌基因组中鉴定出额外的外排系统将促进我们对这些细菌生理学的理解，发现新的耐药分子机制，并揭示它们的耐药潜力。
